From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase SHPRH is an
enzyme that in humans is encoded by the SHPRH
gene .
[5]
[6]
Function
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]
[6]
SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000146414 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000090112 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003).
"Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region" . Genomics . 82 (2): 153–61.
doi :
10.1016/S0888-7543(03)00121-6 .
PMID
12837266 .
^
a
b
"Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase" .
^ Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019).
"The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase" . Epigenetics & Chromatin . 12 (1): 52.
doi :
10.1186/s13072-019-0294-5 .
PMC
6702750 .
PMID
31434570 .
Further reading
Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006).
"Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination" . The Journal of Cell Biology . 175 (5): 703–8.
doi :
10.1083/jcb.200606145 .
PMC
2064669 .
PMID
17130289 .
Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006).
"Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen" . Proceedings of the National Academy of Sciences of the United States of America . 103 (48): 18107–12.
Bibcode :
2006PNAS..10318107U .
doi :
10.1073/pnas.0608595103 .
PMC
1838714 .
PMID
17108083 .
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF) . Current Biology . 14 (16): 1436–50.
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995).
"Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174.
PMID
7566098 .