From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Endophilin-A1 is a
protein that in humans is encoded by the SH3GL2
gene .
[5]
[6]
Interactions
SH3GL2 has been shown to
interact with
DNM1 ,
[7]
[8]
Amphiphysin ,
[7]
[8]
ADAM9 ,
[9]
SH3KBP1
[10] and
ADAM15 .
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000107295 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028488 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Giachino C; Lantelme E; Lanzetti L; Saccone S; Bella Valle G; Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics . 41 (3): 427–34.
doi :
10.1006/geno.1997.4645 .
PMID
9169142 .
^
"Entrez Gene: SH3GL2 SH3-domain GRB2-like 2" .
^
a
b Micheva, K D; Kay B K; McPherson P S (Oct 1997).
"Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin" . J. Biol. Chem . 272 (43). UNITED STATES: 27239–45.
doi :
10.1074/jbc.272.43.27239 .
ISSN
0021-9258 .
PMID
9341169 .
^
a
b Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003).
"Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1" . J. Biol. Chem . 278 (6). United States: 4160–7.
doi :
10.1074/jbc.M208568200 .
ISSN
0021-9258 .
PMID
12456676 .
^
a
b Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999).
"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1" . J. Biol. Chem . 274 (44). UNITED STATES: 31693–9.
doi :
10.1074/jbc.274.44.31693 .
ISSN
0021-9258 .
PMID
10531379 .
^ Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors".
Nature . 416 (6877). England: 183–7.
Bibcode :
2002Natur.416..183S .
doi :
10.1038/416183a .
ISSN
0028-0836 .
PMID
11894095 .
S2CID
635702 .
Further reading
Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. (2008).
"Endophilin I expression is increased in the brains of Alzheimer's disease patients" . Journal of Biological Chemistry . 283 (9): 5685–91.
doi :
10.1074/jbc.M707932200 .
PMID
18167351 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
Reutens AT; Begley CG (2002). "Endophilin-1: a multifunctional protein". Int. J. Biochem. Cell Biol . 34 (10): 1173–7.
doi :
10.1016/S1357-2725(02)00063-8 .
PMID
12127567 .
So CW, Caldas C, Liu MM, et al. (1997).
"EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia" . Proc. Natl. Acad. Sci. U.S.A . 94 (6): 2563–8.
Bibcode :
1997PNAS...94.2563S .
doi :
10.1073/pnas.94.6.2563 .
PMC
20128 .
PMID
9122235 .
Ringstad N; Nemoto Y; De Camilli P (1997).
"The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain" . Proc. Natl. Acad. Sci. U.S.A . 94 (16): 8569–74.
Bibcode :
1997PNAS...94.8569R .
doi :
10.1073/pnas.94.16.8569 .
PMC
23017 .
PMID
9238017 .
Micheva KD; Ramjaun AR; Kay BK; McPherson PS (1997).
"SH3 domain-dependent interactions of endophilin with amphiphysin" . FEBS Lett . 414 (2): 308–12.
doi :
10.1016/S0014-5793(97)01016-8 .
PMID
9315708 .
S2CID
21328416 .
Micheva KD; Kay BK; McPherson PS (1997).
"Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin" . J. Biol. Chem . 272 (43): 27239–45.
doi :
10.1074/jbc.272.43.27239 .
PMID
9341169 .
Howard L; Nelson KK; Maciewicz RA; Blobel CP (1999).
"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1" . J. Biol. Chem . 274 (44): 31693–9.
doi :
10.1074/jbc.274.44.31693 .
PMID
10531379 .
Tang Y, Hu LA, Miller WE, et al. (1999).
"Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor" . Proc. Natl. Acad. Sci. U.S.A . 96 (22): 12559–64.
Bibcode :
1999PNAS...9612559T .
doi :
10.1073/pnas.96.22.12559 .
PMC
22990 .
PMID
10535961 .
Cestra G, Castagnoli L, Dente L, et al. (1999).
"The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity" . J. Biol. Chem . 274 (45): 32001–7.
doi :
10.1074/jbc.274.45.32001 .
PMID
10542231 .
So CW, So CK, Cheung N, et al. (2000).
"The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis" . Leukemia . 14 (4): 594–601.
doi :
10.1038/sj.leu.2401692 .
PMID
10764144 .
So CW, Sham MH, Chew SL, et al. (2000).
"Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins" . Biochem. J . 348 (2): 447–58.
doi :
10.1042/0264-6021:3480447 .
PMC
1221085 .
PMID
10816441 .
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol . 307 (5): 1329–39.
doi :
10.1006/jmbi.2001.4572 .
PMID
11292345 .
Ramjaun AR, Angers A, Legendre-Guillemin V, et al. (2001).
"Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase" . J. Biol. Chem . 276 (31): 28913–9.
doi :
10.1074/jbc.M103198200 .
PMID
11384986 .
Chen-Hwang MC; Chen HR; Elzinga M; Hwang YW (2002).
"Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate" . J. Biol. Chem . 277 (20): 17597–604.
doi :
10.1074/jbc.M111101200 .
PMID
11877424 .
Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . 416 (6877): 183–7.
Bibcode :
2002Natur.416..183S .
doi :
10.1038/416183a .
PMID
11894095 .
S2CID
635702 .
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90.
Bibcode :
2002Natur.416..187P .
doi :
10.1038/416187a .
PMID
11894096 .
S2CID
4389099 .
Chatellard-Causse C, Blot B, Cristina N, et al. (2002).
"Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization" . J. Biol. Chem . 277 (32): 29108–15.
doi :
10.1074/jbc.M204019200 .
PMID
12034747 .
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002).
"CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases" . J. Biol. Chem . 277 (42): 39666–72.
doi :
10.1074/jbc.M205535200 .
PMID
12177062 .
Haglund K; Shimokawa N; Szymkiewicz I; Dikic I (2002).
"Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors" . Proc. Natl. Acad. Sci. U.S.A . 99 (19): 12191–6.
Bibcode :
2002PNAS...9912191H .
doi :
10.1073/pnas.192462299 .
PMC
129420 .
PMID
12218189 .
Verstreken P, Kjaerulff O, Lloyd TE, et al. (2002).
"Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release" . Cell . 109 (1): 101–12.
doi :
10.1016/S0092-8674(02)00688-8 .
PMID
11955450 .
S2CID
11752921 .
PDB gallery
1x03 : Crystal structure of endophilin BAR domain
1zww : Crystal structure of endophilin-A1 BAR domain
2c08 : RAT ENDOPHILIN A1 BAR DOMAIN
2d4c : Crystal structure of the endophilin BAR domain mutant
2dbm : Solution structures of the SH3 domain of human SH3-containing GRB2-like protein 2