Secreted frizzled-related protein 2 is a
protein that in humans is encoded by the SFRP2gene.[5][6]
This gene encodes a member of the SFRP family that contains a
cysteine-rich domain homologous to the putative Wnt-binding site of
Frizzled proteins. SFRPs act as soluble modulators of
Wnt signaling.
Methylation of this gene is a potential marker for the presence of
colorectal cancer.[6]
New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury
[1].
Cancer
SFRP2 gene has been detected progressively overexpressed in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93.
doi:
10.1006/bbrc.1998.8784.
PMID9642118.
Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18.
doi:
10.1242/dev.127.1.109.
PMID10654605.
Secreted frizzled-related protein 2 is a
protein that in humans is encoded by the SFRP2gene.[5][6]
This gene encodes a member of the SFRP family that contains a
cysteine-rich domain homologous to the putative Wnt-binding site of
Frizzled proteins. SFRPs act as soluble modulators of
Wnt signaling.
Methylation of this gene is a potential marker for the presence of
colorectal cancer.[6]
New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury
[1].
Cancer
SFRP2 gene has been detected progressively overexpressed in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93.
doi:
10.1006/bbrc.1998.8784.
PMID9642118.
Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18.
doi:
10.1242/dev.127.1.109.
PMID10654605.