From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
This article is about the human gene. For the submarine communications cable, see
SAT-2. For the SAT II tests, see
SAT Subject Tests.
Diamine acetyltransferase 2 is an
enzyme that in humans is encoded by the SAT2
gene.
[5]
[6]
[7]
SAT2 maintains a key
metabolic
glutamine/
glutamate balance underpinning retrograde signaling by
dendritic release of the
neurotransmitter glutamate.
[8]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000141504 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000069835 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004).
"Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48.
doi:
10.1042/BJ20040790.
PMC
1134097.
PMID
15283699.
-
^ Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007).
"Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80.
doi:
10.1074/jbc.M703504200.
PMID
17558023.
-
^
"Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
-
^ Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009).
"System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106.
doi:
10.1093/cercor/bhn151.
PMID
18832333.
Further reading
- Baek JH, Liu YV, McDonald KR, et al. (2008).
"Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha". J. Biol. Chem. 282 (46): 33358–66.
doi:
10.1074/jbc.M705627200.
PMID
17875644.
- Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR". Mol. Cell. Biochem. 298 (1–2): 59–68.
doi:
10.1007/s11010-006-9350-0.
hdl:
11383/1672116.
PMID
17119850.
S2CID
29889795.
- Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006).
"Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins. 64 (1): 288–93.
doi:
10.1002/prot.20967.
PMID
16596569.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID
16189514.
S2CID
4427026.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5.
Bibcode:
2005Sci...307.1621B.
doi:
10.1126/science.1105776.
PMID
15761153.
S2CID
39457788.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Chen Y, Vujcic S, Liang P, et al. (2003).
"Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase". Biochem. J. 373 (Pt 3): 661–7.
doi:
10.1042/BJ20030734.
PMC
1223561.
PMID
12803540.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.