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Chemical compound
Runcaciguat
![](https://upload.wikimedia.org/wikipedia/commons/thumb/c/cb/Runcaciguat.svg/220px-Runcaciguat.svg.png) |
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(3S)-3-[4-Chloro-3-[[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino]phenyl]-3-cyclopropylpropanoic acid
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Formula | C23H22Cl2F3NO3 |
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Molar mass | 488.33 g·mol−1 |
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3D model (
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C[C@H]([C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=C(C=CC(=C2)[C@@H](CC(=O)O)C3CC3)Cl)C(F)(F)F
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InChI=1S/C23H22Cl2F3NO3/c1-12(23(26,27)28)21(14-4-7-16(24)8-5-14)22(32)29-19-10-15(6-9-18(19)25)17(11-20(30)31)13-2-3-13/h4-10,12-13,17,21H,2-3,11H2,1H3,(H,29,32)(H,30,31)/t12-,17+,21+/m1/s1 Key:NCRMKIWHFXSBGZ-CNBXIYLPSA-N
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Runcaciguat is a
soluble guanylate cyclase stimulator developed by Bayer for non-proliferative
diabetic retinopathy and
chronic kidney disease.
[1]
[2]
[3]
References
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^ Bénardeau, Agnès; Kahnert, Antje; Schomber, Tibor; Meyer, Jutta; Pavkovic, Mira; Kretschmer, Axel; Lawrenz, Bettina; Hartmann, Elke; Mathar, Ilka; Hueser, Joerg; Kraehling, Jan R.; Eitner, Frank; Hahn, Michael G.; Stasch, Johannes-Peter; Sandner, Peter (December 2021).
"Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease". Naunyn-Schmiedeberg's Archives of Pharmacology. 394 (12): 2363–2379.
doi:
10.1007/s00210-021-02149-4.
PMC
8592982.
PMID
34550407.
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^ Hahn, Michael G.; Lampe, Thomas; El Sheikh, Sherif; Griebenow, Nils; Woltering, Elisabeth; Schlemmer, Karl-Heinz; Dietz, Lisa; Gerisch, Michael; Wunder, Frank; Becker-Pelster, Eva-Maria; Mondritzki, Thomas; Tinel, Hanna; Knorr, Andreas; Kern, Armin; Lang, Dieter; Hueser, Joerg; Schomber, Tibor; Benardeau, Agnes; Eitner, Frank; Truebel, Hubert; Mittendorf, Joachim; Kumar, Vijay; van den Akker, Focco; Schaefer, Martina; Geiss, Volker; Sandner, Peter; Stasch, Johannes-Peter (13 May 2021).
"Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)". Journal of Medicinal Chemistry. 64 (9): 5323–5344.
doi:
10.1021/acs.jmedchem.0c02154.
PMID
33872507.
S2CID
233311492.
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^ Nelissen, Ellis; Possemis, Nina; Van Goethem, Nick P.; Schepers, Melissa; Mulder-Jongen, Danielle A. J.; Dietz, Lisa; Janssen, Wiebke; Gerisch, Michael; Hüser, Jörg; Sandner, Peter; Vanmierlo, Tim; Prickaerts, Jos (4 March 2022).
"The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms". Scientific Reports. 12 (1): 3589.
Bibcode:
2022NatSR..12.3589N.
doi:
10.1038/s41598-022-07391-1.
ISSN
2045-2322.
PMC
8897390.
PMID
35246566.