SNP: rs6295 | |
---|---|
Name(s) | C-1019G, C(-1019)G |
Gene | HTR1A |
Chromosome | 5 |
Region | Promoter |
External databases | |
Ensembl | Human SNPView |
dbSNP | 6295 |
HapMap | 6295 |
SNPedia | 6295 |
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene. It is one of the most investigated SNPs of its gene. [1] The C- allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian. [1]
The effect of the SNP on the binding potential of the human 5-HT1A neuroreceptor has been assessed with positron emission tomography and the WAY-100635 radioligand, with a study reporting no apparent influence from the SNP. [2]
The SNP has been investigated for association with suicide attempts, [3] [4] and psychiatric disorders. [1] One study found an association of the variant with schizophrenia. [5] Some studies associate the G-allele or GG-genotype with depression. [3] [6] Not all studies show associations between the disorder and the G-allele. In one study of premenstrual dysphoric disorder C/C was found as the high-risk genotype. [7]
Several studies have examine the SNP association with medical treatment response, e.g., antidepressant response in mood disorders, e.g., one study reported worse response for G-allele patients. [8]
The polymorphism has also been investigated for links to personality traits. Persons with the G- allele of the polymorphism may have higher personality score for the NEO PI-R Neuroticism and TPQ Harm Avoidance traits. [9] However, not all studies can find a clear association. [10] One study has studied another trait and found higher score on Temperament and Character Inventory self-transcendence scale for G-allele subjects among mood disorder patients. [11]
There are a number of other SNPs for the HTR1A gene: C549T, Ile28Val (rs1799921), Pro16Leu (rs1800041), Gly272Asp (rs1800042) and G294A (rs6294). [12]
SNP: rs6295 | |
---|---|
Name(s) | C-1019G, C(-1019)G |
Gene | HTR1A |
Chromosome | 5 |
Region | Promoter |
External databases | |
Ensembl | Human SNPView |
dbSNP | 6295 |
HapMap | 6295 |
SNPedia | 6295 |
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene. It is one of the most investigated SNPs of its gene. [1] The C- allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian. [1]
The effect of the SNP on the binding potential of the human 5-HT1A neuroreceptor has been assessed with positron emission tomography and the WAY-100635 radioligand, with a study reporting no apparent influence from the SNP. [2]
The SNP has been investigated for association with suicide attempts, [3] [4] and psychiatric disorders. [1] One study found an association of the variant with schizophrenia. [5] Some studies associate the G-allele or GG-genotype with depression. [3] [6] Not all studies show associations between the disorder and the G-allele. In one study of premenstrual dysphoric disorder C/C was found as the high-risk genotype. [7]
Several studies have examine the SNP association with medical treatment response, e.g., antidepressant response in mood disorders, e.g., one study reported worse response for G-allele patients. [8]
The polymorphism has also been investigated for links to personality traits. Persons with the G- allele of the polymorphism may have higher personality score for the NEO PI-R Neuroticism and TPQ Harm Avoidance traits. [9] However, not all studies can find a clear association. [10] One study has studied another trait and found higher score on Temperament and Character Inventory self-transcendence scale for G-allele subjects among mood disorder patients. [11]
There are a number of other SNPs for the HTR1A gene: C549T, Ile28Val (rs1799921), Pro16Leu (rs1800041), Gly272Asp (rs1800042) and G294A (rs6294). [12]