| SNP: rs4680 | |
|---|---|
| Name(s) | Val158Met, Val108/158Met, G1947A |
| Gene | COMT |
| Chromosome | 22 |
| Region | Exon 3 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 4680 |
| HapMap | 4680 |
| SNPedia | 4680 |
| AlzGene |
Meta-analysis Overview |
| SzGene |
Meta-analysis Overview |
In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158.
The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.
The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect. [1]
Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking. [2] [3] [4] [5] [6]
References
- ^ "SZGene".
- ^ Martin Reuter & Juergen Hennig (July 2005). "Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion". NeuroReport. 16 (10): 1135–1138. doi: 10.1097/00001756-200507130-00020. PMID 15973162. S2CID 34010109.
-
^
Se Joo Kim,
Young Shin Kim,
Shin Young Kim,
Hong Shick Lee &
Chan-Hyung Kim (June 2006). "An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans".
Neuroscience Letters. 401 (1–2): 154–158.
doi:
10.1016/j.neulet.2006.03.006.
PMID
16584839.
S2CID
26851329.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) -
^
Ryota Hashimoto,
Hiroko Noguchi,
Hiroaki Hori,
Kazutaka Ohi,
Yuka Yasuda,
Masatoshi Takeda &
Hiroshi Kunugi (November 2007). "A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects".
Neuroscience Letters. 428 (1): 17–20.
doi:
10.1016/j.neulet.2007.09.036.
PMID
17945417.
S2CID
28942700.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) -
^
Murray B. Stein,
Margaret Daniele Fallin,
Nicholas J. Schork &
Joel Gelernter (November 2005).
"COMT polymorphisms and anxiety-related personality traits".
Neuropsychopharmacology. 30 (11): 2092–2102.
doi:
10.1038/sj.npp.1300787.
PMID
15956988.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) - ^ Amy L. Silberschmidt & Scott Sponheim (March 2008). "Personality in relation to genetic liability for schizophrenia and bipolar disorder: Differential associations with the COMT Val108/158Met polymorphism". Schizophrenia Research. 100 (1): 316–324. doi: 10.1016/j.schres.2007.12.467. PMC 2682527. PMID 18201871.
| SNP: rs4680 | |
|---|---|
| Name(s) | Val158Met, Val108/158Met, G1947A |
| Gene | COMT |
| Chromosome | 22 |
| Region | Exon 3 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 4680 |
| HapMap | 4680 |
| SNPedia | 4680 |
| AlzGene |
Meta-analysis Overview |
| SzGene |
Meta-analysis Overview |
In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158.
The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.
The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect. [1]
Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking. [2] [3] [4] [5] [6]
References
- ^ "SZGene".
- ^ Martin Reuter & Juergen Hennig (July 2005). "Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion". NeuroReport. 16 (10): 1135–1138. doi: 10.1097/00001756-200507130-00020. PMID 15973162. S2CID 34010109.
-
^
Se Joo Kim,
Young Shin Kim,
Shin Young Kim,
Hong Shick Lee &
Chan-Hyung Kim (June 2006). "An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans".
Neuroscience Letters. 401 (1–2): 154–158.
doi:
10.1016/j.neulet.2006.03.006.
PMID
16584839.
S2CID
26851329.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) -
^
Ryota Hashimoto,
Hiroko Noguchi,
Hiroaki Hori,
Kazutaka Ohi,
Yuka Yasuda,
Masatoshi Takeda &
Hiroshi Kunugi (November 2007). "A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects".
Neuroscience Letters. 428 (1): 17–20.
doi:
10.1016/j.neulet.2007.09.036.
PMID
17945417.
S2CID
28942700.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) -
^
Murray B. Stein,
Margaret Daniele Fallin,
Nicholas J. Schork &
Joel Gelernter (November 2005).
"COMT polymorphisms and anxiety-related personality traits".
Neuropsychopharmacology. 30 (11): 2092–2102.
doi:
10.1038/sj.npp.1300787.
PMID
15956988.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link) - ^ Amy L. Silberschmidt & Scott Sponheim (March 2008). "Personality in relation to genetic liability for schizophrenia and bipolar disorder: Differential associations with the COMT Val108/158Met polymorphism". Schizophrenia Research. 100 (1): 316–324. doi: 10.1016/j.schres.2007.12.467. PMC 2682527. PMID 18201871.