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Robin Allshire
FRS FRSE
Robin Allshire in 2019
Born
Robin Campbell Allshire

1960 (age 63–64)
Alma mater Trinity College Dublin (BSc)
University of Edinburgh (PhD)
Scientific career
Fields Epigenetics
Heterochromatin
Chromatin
Centromere
Kinetochore [1]
Institutions University of Edinburgh
Cold Spring Harbor Laboratory
Thesis Construction and analysis of vectors based on bovine papilloma virus (1985)
Doctoral advisorChris Bostock
Edwin Southern [2]
Other academic advisors Nicholas Hastie
Website allshirelab.com

Robin Campbell Allshire (born 19 May 1960) FRS FRSE FMedSci [3] [4] [5] is Professor of Chromosome Biology [6] at University of Edinburgh and a Wellcome Trust Principal Research Fellow. [7] [1] His research group at the Wellcome Trust Centre for Cell Biology [8] focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division. [9]

Early life and education

Allshire grew up in the fishing village of Howth, Co Dublin 1960–1978.[ citation needed] His parents were Arthur Gordon Allshire (1925-2012) who was a Pharmacist and Freda Margaret (née Schmutz; 1933–2014). [10] [11] He was awarded his Bachelor of Arts degree in Genetics by Trinity College Dublin, in 1981[ citation needed] where he was motivated by the inspirational teaching of David McConnell and colleagues at the Dept of Genetics to undertake post-graduate studies. [12] He subsequently joined the Medical Research Council (MRC) Mammalian Genome Unit at the University of Edinburgh where he obtained his PhD in 1985 [2] under the guidance of Chris Bostock and Edwin Southern investigating the use of bovine papillomavirus as a chassis for mammalian artificial chromosome construction. [2]

Career and research

In 1985 Allshire joined Nicholas Hastie's research group at the MRC Human Genetics Unit, Edinburgh (formerly MRC Clinical and Population Cytogentics Unit) as a postdoctoral researcher where he discovered that mammalian telomeres are composed of simple repetitive sequences similar to those of unicellular eukaryotes [13] and that telomere length in blood cells shorten with age and are further eroded in cancerous cells. [14] This work resulted from following the fate of fission yeast ( Schizosaccharomyces pombe) telomeres after introdroducing fission yeast chromosomes into mouse cell in collaboration with Peter Fantes. [15] In 1989 he took a position as an independent visiting scientist at Cold Spring Harbor Laboratory (CSHL) for 18 months before joining the MRC Human Genetics Unit as a junior group leader. While at CSHL he decided to switch his focus to investigating chromosomal elements in the genetically tractable fission yeast. [16] At the MRC HGU, Edinburgh (1990 - 2002), and subsequently at the Wellome Trust Centre for Cell Biology, University of Edinburgh (2002–present), he discovered that genes are silenced when placed within fission yeast centromeres [17] [18] and telomeres, [19] and then utilised this gene silencing to gain fundamental insights into the processes of chromosome segregation, [20] [21] [22] and heterochromatin [23] [24] [25] [26] and kinetochore CENP-A chromatin [27] [28] [29] [30] [31] [32] establishment [33] [34] and maintenance. [35] [36] [37] He is particularly interested in the epigenetic mechanisms that allow the persistence of specialised chromatin domains through multiple cell divisions and meiosis. [38] He has investigated how RNA interference (RNAi) mediates heterochromatin formation [39] [40] [41] and shown that splicing factors contribute to heterochromatin integrity via siRNA generation and RNAi. [42] [43] He has provided insight into how transcription and resulting non-coding RNA might influence the assembly of specialised CENP-A chromatin [44] [45] [46] [47] and demonstrated that some acts of lncRNA transcription are responsive to environmental stimuli and regulate neighbouring genes by transcriptional interference. [48] [49] Recently using fission yeast his team discovered an epigenetic mechanism that allows fungi to develop resistance to antifungal drugs without alterations to their DNA. [50] This finding is important for understanding how pathogenic fungi become resistant to the limited number of available antifungal agents in both clinical and agricultural arenas.

Awards and honours

Allshire was elected a Fellow of the Royal Society of Edinburgh in 2005, [51] a Fellow of the Royal Society (FRS) in 2011 [4] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2020. [5]

References

  1. ^ a b Robin Allshire publications indexed by Google Scholar Edit this at Wikidata
  2. ^ a b c Allshire, Robin Campbell (1985). Construction and analysis of vectors based on bovine papilloma virus (PhD thesis). University of Edinburgh. hdl: 1842/11176. OCLC  606010479. EThOS  uk.bl.ethos.355979. Free access icon
  3. ^ "Professor Robin Campbell Allshire FRS, FRSE". rse.org.uk. 24 August 2020.
  4. ^ a b Anon (2011). "Professor Robin Allshire FRS". royalsociety.org. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  5. ^ a b "Professor Robin Allshire | the Academy of Medical Sciences". Academy of Medical Sciences.
  6. ^ "Allshire lab members".
  7. ^ "Principal Research Fellowships: people we've funded". wellcome.ac.uk. Wellcome Trust.
  8. ^ "Wellcome Centre for Cell Biology - Wellcome Centre for Cell Biology". University of Edinburgh.
  9. ^ "Wellcome Trust lab". 11 January 2024.
  10. ^ "ALLSHIRE, Arthur : Death notice - Irish Times Family Notices". The Irish Times.
  11. ^ "ALLSHIRE, Freda Margaret : Death notice - Irish Times Family Notices". The Irish Times.
  12. ^ "EPIGENETICS AND SPECIALIZED CHROMATIN".
  13. ^ Allshire, Robin C; Gosden, John R; Cross, Sally H; Cranston, Gwen; Rout, Derek; Sugawara, Neal; Szostak, Jack W; Fantes, Peter A; Hastie, Nicholas D (1988). "Telomeric repeat from T. Thermophila cross hybridizes with human telomeres". Nature. 332 (6165): 656–9. Bibcode: 1988Natur.332..656A. doi: 10.1038/332656a0. PMID  2833706. S2CID  4352376.
  14. ^ Hastie, Nicholas D; Dempster, Maureen; Dunlop, Malcolm G; Thompson, Alastair M; Green, Daryll K; Allshire, Robin C (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. Bibcode: 1990Natur.346..866H. doi: 10.1038/346866a0. PMID  2392154. S2CID  4258451.
  15. ^ Allshire, R. C; Cranston, G; Gosden, J. R; Maule, J. C; Hastie, N. D; Fantes, P. A (1987). "A fission yeast chromosome can replicate autonomously in mouse cells". Cell. 50 (3): 391–403. doi: 10.1016/0092-8674(87)90493-4. PMID  3475186. S2CID  2193386.
  16. ^ Allshire, R. C (1990). "Introduction of large linear minichromosomes into Schizosaccharomyces pombe by an improved transformation procedure". Proceedings of the National Academy of Sciences of the United States of America. 87 (11): 4043–7. Bibcode: 1990PNAS...87.4043A. doi: 10.1073/pnas.87.11.4043. PMC  54043. PMID  2349217.
  17. ^ Allshire, R. C; Javerzat, J. P; Redhead, N. J; Cranston, G (1994). "Position effect variegation at fission yeast centromeres". Cell. 76 (1): 157–69. doi: 10.1016/0092-8674(94)90180-5. PMID  8287474. S2CID  42369473.
  18. ^ Allshire, R. C; Nimmo, E. R; Ekwall, K; Javerzat, J. P; Cranston, G (1995). "Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation". Genes & Development. 9 (2): 218–33. doi: 10.1101/gad.9.2.218. PMID  7851795.
  19. ^ Nimmo, E. R; Cranston, G; Allshire, R. C (1994). "Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes". The EMBO Journal. 13 (16): 3801–11. doi: 10.1002/j.1460-2075.1994.tb06691.x. PMC  395293. PMID  8070408.
  20. ^ Nimmo, Elaine R; Pidoux, Alison L; Perry, Paul E; Allshire, Robin C (1998). "Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe". Nature. 392 (6678): 825–8. Bibcode: 1998Natur.392..825N. doi: 10.1038/33941. PMID  9572142. S2CID  4412433.
  21. ^ Pidoux, A. L; Uzawa, S; Perry, P. E; Cande, W. Z; Allshire, R. C (2000). "Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast". Journal of Cell Science. 113 Pt 23 (23): 4177–91. doi: 10.1242/jcs.113.23.4177. PMID  11069763.
  22. ^ Bernard, P; Maure, J. F; Partridge, J. F; Genier, S; Javerzat, J. P; Allshire, R. C (2001). "Requirement of Heterochromatin for Cohesion at Centromeres". Science. 294 (5551): 2539–42. Bibcode: 2001Sci...294.2539B. doi: 10.1126/science.1064027. PMID  11598266. S2CID  31166180.
  23. ^ Ekwall, K; Javerzat, J. P; Lorentz, A; Schmidt, H; Cranston, G; Allshire, R (1995). "The chromodomain protein Swi6: A key component at fission yeast centromeres". Science. 269 (5229): 1429–31. Bibcode: 1995Sci...269.1429E. doi: 10.1126/science.7660126. PMID  7660126. S2CID  38678389.
  24. ^ Ekwall, K; Olsson, T; Turner, B. M; Cranston, G; Allshire, R. C (1997). "Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres". Cell. 91 (7): 1021–32. doi: 10.1016/S0092-8674(00)80492-4. PMID  9428524.
  25. ^ Bannister, Andrew J; Zegerman, Philip; Partridge, Janet F; Miska, Eric A; Thomas, Jean O; Allshire, Robin C; Kouzarides, Tony (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature. 410 (6824): 120–4. Bibcode: 2001Natur.410..120B. doi: 10.1038/35065138. PMID  11242054. S2CID  4334447.
  26. ^ Partridge, J. F; Scott, K. S; Bannister, A. J; Kouzarides, T; Allshire, R. C (2002). "Cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site". Current Biology. 12 (19): 1652–60. doi: 10.1016/S0960-9822(02)01177-6. PMID  12361567.
  27. ^ Pidoux, Alison L; Richardson, William; Allshire, Robin C (2003). "Sim4". The Journal of Cell Biology. 161 (2): 295–307. doi: 10.1083/jcb.200212110. PMC  2172903. PMID  12719471.
  28. ^ Castillo, A. G; Mellone, B. G; Partridge, J. F; Richardson, W; Hamilton, G. L; Allshire, R. C; Pidoux, A. L (2007). "Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4". PLOS Genetics. 3 (7): e121. doi: 10.1371/journal.pgen.0030121. PMC  1934396. PMID  17677001.
  29. ^ Dunleavy, Elaine M; Pidoux, Alison L; Monet, Marie; Bonilla, Carolina; Richardson, William; Hamilton, Georgina L; Ekwall, Karl; McLaughlin, Paul J; Allshire, Robin C (2007). "A NASP (N1/N2)-Related Protein, Sim3, Binds CENP-A and is Required for Its Deposition at Fission Yeast Centromeres". Molecular Cell. 28 (6): 1029–44. doi: 10.1016/j.molcel.2007.10.010. PMC  2193228. PMID  18158900.
  30. ^ Pidoux, Alison L; Choi, Eun Shik; Abbott, Johanna K.R; Liu, Xingkun; Kagansky, Alexander; Castillo, Araceli G; Hamilton, Georgina L; Richardson, William; Rappsilber, Juri; He, Xiangwei; Allshire, Robin C (2009). "Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin". Molecular Cell. 33 (3): 299–311. doi: 10.1016/j.molcel.2009.01.019. PMC  2697330. PMID  19217404.
  31. ^ Sanchez-Pulido, Luis; Pidoux, Alison L; Ponting, Chris P; Allshire, Robin C (2009). "Common Ancestry of the CENP-A Chaperones Scm3 and HJURP". Cell. 137 (7): 1173–4. doi: 10.1016/j.cell.2009.06.010. PMC  4397584. PMID  19563746.
  32. ^ Subramanian, L; Toda, N. R. T; Rappsilber, J; Allshire, R. C (2014). "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly". Open Biology. 4 (4): 140043. doi: 10.1098/rsob.140043. PMC  4043117. PMID  24789708.
  33. ^ Folco, H. D; Pidoux, A. L; Urano, T; Allshire, R. C (2008). "Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres". Science. 319 (5859): 94–7. Bibcode: 2008Sci...319...94F. doi: 10.1126/science.1150944. PMC  2586718. PMID  18174443.
  34. ^ Kagansky, A; Folco, H. D; Almeida, R; Pidoux, A. L; Boukaba, A; Simmer, F; Urano, T; Hamilton, G. L; Allshire, R. C (2009). "Synthetic Heterochromatin Bypasses RNAi and Centromeric Repeats to Establish Functional Centromeres". Science. 324 (5935): 1716–9. Bibcode: 2009Sci...324.1716K. doi: 10.1126/science.1172026. PMC  2949999. PMID  19556509.
  35. ^ Partridge, J. F; Borgstrøm, B; Allshire, R. C (2000). "Distinct protein interaction domains and protein spreading in a complex centromere". Genes & Development. 14 (7): 783–91. doi: 10.1101/gad.14.7.783. PMC  316498. PMID  10766735.
  36. ^ Trewick, Sarah C; Minc, Elsa; Antonelli, Richard; Urano, Takeshi; Allshire, Robin C (2007). "The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin". The EMBO Journal. 26 (22): 4670–82. doi: 10.1038/sj.emboj.7601892. PMC  2048757. PMID  17948055.
  37. ^ Buscaino, Alessia; Lejeune, Erwan; Audergon, Pauline; Hamilton, Georgina; Pidoux, Alison; Allshire, Robin C (2013). "Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance". The EMBO Journal. 32 (9): 1250–64. doi: 10.1038/emboj.2013.72. PMC  3642681. PMID  23572080.
  38. ^ Audergon, P. N. C. B; Catania, S; Kagansky, A; Tong, P; Shukla, M; Pidoux, A. L; Allshire, R. C (2015). "Restricted epigenetic inheritance of H3K9 methylation". Science. 348 (6230): 132–5. Bibcode: 2015Sci...348..132A. doi: 10.1126/science.1260638. PMC  4397586. PMID  25838386.
  39. ^ Simmer, Femke; Buscaino, Alessia; Kos-Braun, Isabelle C; Kagansky, Alexander; Boukaba, Abdelhalim; Urano, Takeshi; Kerr, Alastair R W; Allshire, Robin C (2010). "Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast". EMBO Reports. 11 (2): 112–8. doi: 10.1038/embor.2009.273. PMC  2828748. PMID  20062003.
  40. ^ Bayne, Elizabeth H; White, Sharon A; Kagansky, Alexander; Bijos, Dominika A; Sanchez-Pulido, Luis; Hoe, Kwang-Lae; Kim, Dong-Uk; Park, Han-Oh; Ponting, Chris P; Rappsilber, Juri; Allshire, Robin C (2010). "Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity". Cell. 140 (5): 666–77. doi: 10.1016/j.cell.2010.01.038. PMC  2875855. PMID  20211136.
  41. ^ Buscaino, Alessia; White, Sharon A; Houston, Douglas R; Lejeune, Erwan; Simmer, Femke; De Lima Alves, Flavia; Diyora, Piyush T; Urano, Takeshi; Bayne, Elizabeth H; Rappsilber, Juri; Allshire, Robin C (2012). "Raf1 is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification". PLOS Genetics. 8 (2): e1002499. doi: 10.1371/journal.pgen.1002499. PMC  3271066. PMID  22319459.
  42. ^ Bayne, E. H; Portoso, M; Kagansky, A; Kos-Braun, I. C; Urano, T; Ekwall, K; Alves, F; Rappsilber, J; Allshire, R. C (2008). "Splicing Factors Facilitate RNAi-Directed Silencing in Fission Yeast". Science. 322 (5901): 602–6. Bibcode: 2008Sci...322..602B. doi: 10.1126/science.1164029. PMC  2585287. PMID  18948543.
  43. ^ Bayne, Elizabeth H; Bijos, Dominika A; White, Sharon A; Alves, Flavia de Lima; Rappsilber, Juri; Allshire, Robin C (2014). "A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast". Genome Biology. 15 (10): 481. doi: 10.1186/s13059-014-0481-4. PMC  4210515. PMID  25274039.
  44. ^ Choi, Eun Shik; Strålfors, Annelie; Castillo, Araceli G; Durand-Dubief, Mickaël; Ekwall, Karl; Allshire, Robin C (2011). "Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres". Journal of Biological Chemistry. 286 (26): 23600–7. doi: 10.1074/jbc.M111.228510. PMC  3123123. PMID  21531710.
  45. ^ Choi, Eun Shik; Strålfors, Annelie; Catania, Sandra; Castillo, Araceli G; Svensson, J. Peter; Pidoux, Alison L; Ekwall, Karl; Allshire, Robin C (2012). "Factors That Promote H3 Chromatin Integrity during Transcription Prevent Promiscuous Deposition of CENP-ACnp1 in Fission Yeast". PLOS Genetics. 8 (9): e1002985. doi: 10.1371/journal.pgen.1002985. PMC  3447972. PMID  23028377.
  46. ^ Catania, Sandra; Pidoux, Alison L; Allshire, Robin C (2015). "Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin". PLOS Genetics. 11 (3): e1004986. doi: 10.1371/journal.pgen.1004986. PMC  4349457. PMID  25738810.
  47. ^ Shukla M, Manu; Allshire, Robin C (2018). "Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle". Current Biology. 28 (24): 3924–3936. doi: 10.1016/j.cub.2018.10.049. PMC  6303189. PMID  30503616.
  48. ^ Ard, Ryan; Tong, Pin; Allshire, Robin C (2014). "Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast". Nature Communications. 5: 5576. Bibcode: 2014NatCo...5.5576A. doi: 10.1038/ncomms6576. PMC  4255232. PMID  25428589.
  49. ^ Ard, Ryan; Allshire, Robin C (2016). "Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference". Nucleic Acids Research. 44 (22): 10619–10630. doi: 10.1093/nar/gkw801. PMC  5159543. PMID  27613421.
  50. ^ Torres-Garcia, Sito (2020). "Epigenetic gene silencing by heterochromatin primes fungal resistance". Nature. 585 (7825): 453–458. Bibcode: 2020Natur.585..453T. doi: 10.1038/s41586-020-2706-x. PMC  7116710. PMID  32908306.
  51. ^ "biography". ICG. Retrieved 4 December 2018.
  52. ^ "Genetics Society Medal 2013". Genetics Society. Retrieved 4 December 2018.

 This article incorporates text available under the CC BY 4.0 license.

Retrieved from " https://en.wikipedia.org/?title=Robin_Allshire&oldid=1221398256"
From Wikipedia, the free encyclopedia

Robin Allshire
FRS FRSE
Robin Allshire in 2019
Born
Robin Campbell Allshire

1960 (age 63–64)
Alma mater Trinity College Dublin (BSc)
University of Edinburgh (PhD)
Scientific career
Fields Epigenetics
Heterochromatin
Chromatin
Centromere
Kinetochore [1]
Institutions University of Edinburgh
Cold Spring Harbor Laboratory
Thesis Construction and analysis of vectors based on bovine papilloma virus (1985)
Doctoral advisorChris Bostock
Edwin Southern [2]
Other academic advisors Nicholas Hastie
Website allshirelab.com

Robin Campbell Allshire (born 19 May 1960) FRS FRSE FMedSci [3] [4] [5] is Professor of Chromosome Biology [6] at University of Edinburgh and a Wellcome Trust Principal Research Fellow. [7] [1] His research group at the Wellcome Trust Centre for Cell Biology [8] focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division. [9]

Early life and education

Allshire grew up in the fishing village of Howth, Co Dublin 1960–1978.[ citation needed] His parents were Arthur Gordon Allshire (1925-2012) who was a Pharmacist and Freda Margaret (née Schmutz; 1933–2014). [10] [11] He was awarded his Bachelor of Arts degree in Genetics by Trinity College Dublin, in 1981[ citation needed] where he was motivated by the inspirational teaching of David McConnell and colleagues at the Dept of Genetics to undertake post-graduate studies. [12] He subsequently joined the Medical Research Council (MRC) Mammalian Genome Unit at the University of Edinburgh where he obtained his PhD in 1985 [2] under the guidance of Chris Bostock and Edwin Southern investigating the use of bovine papillomavirus as a chassis for mammalian artificial chromosome construction. [2]

Career and research

In 1985 Allshire joined Nicholas Hastie's research group at the MRC Human Genetics Unit, Edinburgh (formerly MRC Clinical and Population Cytogentics Unit) as a postdoctoral researcher where he discovered that mammalian telomeres are composed of simple repetitive sequences similar to those of unicellular eukaryotes [13] and that telomere length in blood cells shorten with age and are further eroded in cancerous cells. [14] This work resulted from following the fate of fission yeast ( Schizosaccharomyces pombe) telomeres after introdroducing fission yeast chromosomes into mouse cell in collaboration with Peter Fantes. [15] In 1989 he took a position as an independent visiting scientist at Cold Spring Harbor Laboratory (CSHL) for 18 months before joining the MRC Human Genetics Unit as a junior group leader. While at CSHL he decided to switch his focus to investigating chromosomal elements in the genetically tractable fission yeast. [16] At the MRC HGU, Edinburgh (1990 - 2002), and subsequently at the Wellome Trust Centre for Cell Biology, University of Edinburgh (2002–present), he discovered that genes are silenced when placed within fission yeast centromeres [17] [18] and telomeres, [19] and then utilised this gene silencing to gain fundamental insights into the processes of chromosome segregation, [20] [21] [22] and heterochromatin [23] [24] [25] [26] and kinetochore CENP-A chromatin [27] [28] [29] [30] [31] [32] establishment [33] [34] and maintenance. [35] [36] [37] He is particularly interested in the epigenetic mechanisms that allow the persistence of specialised chromatin domains through multiple cell divisions and meiosis. [38] He has investigated how RNA interference (RNAi) mediates heterochromatin formation [39] [40] [41] and shown that splicing factors contribute to heterochromatin integrity via siRNA generation and RNAi. [42] [43] He has provided insight into how transcription and resulting non-coding RNA might influence the assembly of specialised CENP-A chromatin [44] [45] [46] [47] and demonstrated that some acts of lncRNA transcription are responsive to environmental stimuli and regulate neighbouring genes by transcriptional interference. [48] [49] Recently using fission yeast his team discovered an epigenetic mechanism that allows fungi to develop resistance to antifungal drugs without alterations to their DNA. [50] This finding is important for understanding how pathogenic fungi become resistant to the limited number of available antifungal agents in both clinical and agricultural arenas.

Awards and honours

Allshire was elected a Fellow of the Royal Society of Edinburgh in 2005, [51] a Fellow of the Royal Society (FRS) in 2011 [4] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2020. [5]

References

  1. ^ a b Robin Allshire publications indexed by Google Scholar Edit this at Wikidata
  2. ^ a b c Allshire, Robin Campbell (1985). Construction and analysis of vectors based on bovine papilloma virus (PhD thesis). University of Edinburgh. hdl: 1842/11176. OCLC  606010479. EThOS  uk.bl.ethos.355979. Free access icon
  3. ^ "Professor Robin Campbell Allshire FRS, FRSE". rse.org.uk. 24 August 2020.
  4. ^ a b Anon (2011). "Professor Robin Allshire FRS". royalsociety.org. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  5. ^ a b "Professor Robin Allshire | the Academy of Medical Sciences". Academy of Medical Sciences.
  6. ^ "Allshire lab members".
  7. ^ "Principal Research Fellowships: people we've funded". wellcome.ac.uk. Wellcome Trust.
  8. ^ "Wellcome Centre for Cell Biology - Wellcome Centre for Cell Biology". University of Edinburgh.
  9. ^ "Wellcome Trust lab". 11 January 2024.
  10. ^ "ALLSHIRE, Arthur : Death notice - Irish Times Family Notices". The Irish Times.
  11. ^ "ALLSHIRE, Freda Margaret : Death notice - Irish Times Family Notices". The Irish Times.
  12. ^ "EPIGENETICS AND SPECIALIZED CHROMATIN".
  13. ^ Allshire, Robin C; Gosden, John R; Cross, Sally H; Cranston, Gwen; Rout, Derek; Sugawara, Neal; Szostak, Jack W; Fantes, Peter A; Hastie, Nicholas D (1988). "Telomeric repeat from T. Thermophila cross hybridizes with human telomeres". Nature. 332 (6165): 656–9. Bibcode: 1988Natur.332..656A. doi: 10.1038/332656a0. PMID  2833706. S2CID  4352376.
  14. ^ Hastie, Nicholas D; Dempster, Maureen; Dunlop, Malcolm G; Thompson, Alastair M; Green, Daryll K; Allshire, Robin C (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. Bibcode: 1990Natur.346..866H. doi: 10.1038/346866a0. PMID  2392154. S2CID  4258451.
  15. ^ Allshire, R. C; Cranston, G; Gosden, J. R; Maule, J. C; Hastie, N. D; Fantes, P. A (1987). "A fission yeast chromosome can replicate autonomously in mouse cells". Cell. 50 (3): 391–403. doi: 10.1016/0092-8674(87)90493-4. PMID  3475186. S2CID  2193386.
  16. ^ Allshire, R. C (1990). "Introduction of large linear minichromosomes into Schizosaccharomyces pombe by an improved transformation procedure". Proceedings of the National Academy of Sciences of the United States of America. 87 (11): 4043–7. Bibcode: 1990PNAS...87.4043A. doi: 10.1073/pnas.87.11.4043. PMC  54043. PMID  2349217.
  17. ^ Allshire, R. C; Javerzat, J. P; Redhead, N. J; Cranston, G (1994). "Position effect variegation at fission yeast centromeres". Cell. 76 (1): 157–69. doi: 10.1016/0092-8674(94)90180-5. PMID  8287474. S2CID  42369473.
  18. ^ Allshire, R. C; Nimmo, E. R; Ekwall, K; Javerzat, J. P; Cranston, G (1995). "Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation". Genes & Development. 9 (2): 218–33. doi: 10.1101/gad.9.2.218. PMID  7851795.
  19. ^ Nimmo, E. R; Cranston, G; Allshire, R. C (1994). "Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes". The EMBO Journal. 13 (16): 3801–11. doi: 10.1002/j.1460-2075.1994.tb06691.x. PMC  395293. PMID  8070408.
  20. ^ Nimmo, Elaine R; Pidoux, Alison L; Perry, Paul E; Allshire, Robin C (1998). "Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe". Nature. 392 (6678): 825–8. Bibcode: 1998Natur.392..825N. doi: 10.1038/33941. PMID  9572142. S2CID  4412433.
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  25. ^ Bannister, Andrew J; Zegerman, Philip; Partridge, Janet F; Miska, Eric A; Thomas, Jean O; Allshire, Robin C; Kouzarides, Tony (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature. 410 (6824): 120–4. Bibcode: 2001Natur.410..120B. doi: 10.1038/35065138. PMID  11242054. S2CID  4334447.
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  27. ^ Pidoux, Alison L; Richardson, William; Allshire, Robin C (2003). "Sim4". The Journal of Cell Biology. 161 (2): 295–307. doi: 10.1083/jcb.200212110. PMC  2172903. PMID  12719471.
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  29. ^ Dunleavy, Elaine M; Pidoux, Alison L; Monet, Marie; Bonilla, Carolina; Richardson, William; Hamilton, Georgina L; Ekwall, Karl; McLaughlin, Paul J; Allshire, Robin C (2007). "A NASP (N1/N2)-Related Protein, Sim3, Binds CENP-A and is Required for Its Deposition at Fission Yeast Centromeres". Molecular Cell. 28 (6): 1029–44. doi: 10.1016/j.molcel.2007.10.010. PMC  2193228. PMID  18158900.
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  31. ^ Sanchez-Pulido, Luis; Pidoux, Alison L; Ponting, Chris P; Allshire, Robin C (2009). "Common Ancestry of the CENP-A Chaperones Scm3 and HJURP". Cell. 137 (7): 1173–4. doi: 10.1016/j.cell.2009.06.010. PMC  4397584. PMID  19563746.
  32. ^ Subramanian, L; Toda, N. R. T; Rappsilber, J; Allshire, R. C (2014). "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly". Open Biology. 4 (4): 140043. doi: 10.1098/rsob.140043. PMC  4043117. PMID  24789708.
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  48. ^ Ard, Ryan; Tong, Pin; Allshire, Robin C (2014). "Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast". Nature Communications. 5: 5576. Bibcode: 2014NatCo...5.5576A. doi: 10.1038/ncomms6576. PMC  4255232. PMID  25428589.
  49. ^ Ard, Ryan; Allshire, Robin C (2016). "Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference". Nucleic Acids Research. 44 (22): 10619–10630. doi: 10.1093/nar/gkw801. PMC  5159543. PMID  27613421.
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  51. ^ "biography". ICG. Retrieved 4 December 2018.
  52. ^ "Genetics Society Medal 2013". Genetics Society. Retrieved 4 December 2018.

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