rncO | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of rncO | |
Identifiers | |
Symbol | rncO |
Rfam | RF00552 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Bacteria |
SO | SO:0000233 |
PDB structures | PDBe |
RncO is a bacterial non-coding RNA regulatory element found in the rnc leader sequence. The rnc operon is negatively auto-regulated by transcript stability. rnc, the first gene in the operon codes for RNase III which cleaves the long rncO stem II leading to transcript degradation and a reduction in translation. [1] Matsunaga et al. showed that RNase III cleavage can initiate rnc transcript decay independently of rnc gene translation. [2] Further work has established that rncO structure and function is conserved in Salmonella typhimurium. [3]
Functionally the first 215 nucleotides of the rnc leader have been shown to be sufficient. Within this region three stem-loops were identified. Stem-loop II is cleaved by RNase III, whereas stem-loops I and III are important for stability. [1]
rncO | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of rncO | |
Identifiers | |
Symbol | rncO |
Rfam | RF00552 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Bacteria |
SO | SO:0000233 |
PDB structures | PDBe |
RncO is a bacterial non-coding RNA regulatory element found in the rnc leader sequence. The rnc operon is negatively auto-regulated by transcript stability. rnc, the first gene in the operon codes for RNase III which cleaves the long rncO stem II leading to transcript degradation and a reduction in translation. [1] Matsunaga et al. showed that RNase III cleavage can initiate rnc transcript decay independently of rnc gene translation. [2] Further work has established that rncO structure and function is conserved in Salmonella typhimurium. [3]
Functionally the first 215 nucleotides of the rnc leader have been shown to be sufficient. Within this region three stem-loops were identified. Stem-loop II is cleaved by RNase III, whereas stem-loops I and III are important for stability. [1]