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Rickettsia parkeri
Four photos showing skin problems, one of them taken through a microscope.
Rickettsia parkeri rickettsiosis skin lesions: A - eschar after tick bite on neck; B, C - papulovesicular rash on back and leg; D - micrograph of biopsy specimen
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species group: Spotted fever group
Species:
R. parkeri
Binomial name
Rickettsia parkeri
Lackman et al., 1965

Rickettsia parkeri (abbreviated R. parkeri) is a gram-negative intracellular bacterium. The organism is found in the Western Hemisphere and is transmitted via the bite of hard ticks of the genus Amblyomma. R. parkeri causes mild spotted fever disease in humans, whose most common signs and symptoms are fever, an eschar at the site of tick attachment, rash, headache, and muscle aches. Doxycycline is the most common drug used to reduce the symptoms associated with disease.

Biology

R. parkeri is classified in the spotted fever group of the genus Rickettsia. [1] [2] Genetically, its close relatives include R. africae, R. sibirica, R. conorii, R. rickettsii, R. peacockii, and R. honei. [1]

The organism has been isolated from numerous species of ticks in the genus Amblyomma: A. americanum in the United States; A. aureolatum in Brazil; A. maculatum in Mexico, Peru, and the United States; A. nodosum in Brazil; A. ovale in Brazil and Mexico; A. parvitarsum in Argentina and Chile; A. tigrinum in Argentina, Bolivia, Brazil, and Uruguay; and A. triste in Argentina, Brazil, the United States, and Uruguay. [2] [3] [4] [5] Different ticks may carry different strains of the organism. R. parkeri sensu stricto ("in the strict sense") is found in A. maculatum and A. triste; R. parkeri strain NOD, in A. nodosum; R. parkeri strain Parvitarsum, in A. parvitarsum; and R. parkeri strain Atlantic rainforest, in A. aureolatum and A. ovale. [2]

Human infections

The first report of a confirmed human case of infection with R. parkeri was published in 2004. [6] [7] The person was infected in the state of Virginia in the United States. [6] Other confirmed or probable human cases have been reported to have acquired infection elsewhere in the United States (e.g., Arizona, Georgia, and Mississippi), as well as in Argentina, Brazil, Colombia, Mexico, and Uruguay. [8] [9] Terms used to describe human infection with R. parkeri include "American boutonneuse fever" because of its similarity to boutonneuse fever caused by Rickettsia conorii; [10] " American tick bite fever" because of its similarity to African tick bite fever caused by Rickettsia africae; [11] "Tidewater spotted fever," after the Tidewater region in the eastern United States; [12] and "Rickettsia parkeri rickettsiosis" or "R. parkeri rickettsiosis." [7] [12]

Epidemiology

Of all human cases documented in the medical literature, 87% were 18-64 years of age, and most cases were male. [8] Brazil, Argentina, and the United States accounted for the majority of cases in the medical literature. [8] In the United States, most of the 40 cases reported to the Centers for Disease Control and Prevention (CDC) as of 2016 became infected between the months of July and September. [13]: 5–6 

Diagnosis

The CDC recommends polymerase chain reaction (PCR) of a biopsy or swab of an eschar, or PCR of a biopsy of a rash, for diagnosis of R. parkeri infection. [13]: 27  In addition, indirect immunofluorescence antibody (IFA) assays using paired acute and convalescent sera can be used. [13]: 27 

Clinical manifestations

A 2008 study compared 12 R. parkeri cases with 208 Rocky Mountain spotted fever cases caused by R. rickettsii. [7] Although both R. parkeri and R. rickettsii caused fever, rash, myalgia, and headache, R. parkeri caused eschars and R. rickettsii did not. [7] Furthermore, the percentage of patients hospitalized was lower for R. parkeri than for R. rickettsii (33% vs 78%), and R. parkeri led to no deaths while R. rickettsii led to death in 7% of cases. [7]

A 2021 systematic review of 32 confirmed and 45 probable cases of human infection with R. parkeri determined that 94% of the confirmed cases had fever, 91% an eschar, 72% a rash, 56% headache, and 56% myalgia, with similar percentages among the probable cases. [8] The rash was most frequently described as papular or macular. [8] Among the confirmed and probable cases, the most common treatment was doxycycline, followed by tetracycline. [8] Although 9% of all the cases were hospitalized, there was a "100% rate of clinical recovery." [8]

History

In 1939, Ralph R. Parker, director of the Rocky Mountain Laboratory, and others published a paper on "a rickettsia-like infectious agent." [7] [14] The agent, found in Amblyomma maculatum ticks collected from cows in Texas, produced mild disease in guinea pigs. [7] [14] In 1965, Lackman and others named the rickettsial organism R. parkeri after Parker. [2] [15]

References

  1. ^ a b Perlman SJ, Hunter MS, Zchori-Fein E (2006). "The emerging diversity of Rickettsia". Proc Biol Sci. 273 (1598): 2097–2106. doi: 10.1098/rspb.2006.3541. PMC  1635513. PMID  16901827.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  2. ^ a b c d Nieri-Bastos FA, Marcili A, De Sousa R, Paddock CD, Labruna MB (2018). "Phylogenetic evidence for the existence of multiple strains of Rickettsia parkeri in the New World". Appl Environ Microbiol. 84 (8): e02872–17. Bibcode: 2018ApEnM..84E2872N. doi: 10.1128/AEM.02872-17. PMC  5881050. PMID  29439989.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  3. ^ Cohen SB, Yabsley MJ, Garrison LE, Freye JD, Dunlap BG, Dunn JR; et al. (2009). "Rickettsia parkeri in Amblyomma americanum ticks, Tennessee and Georgia, USA". Emerg Infect Dis. 15 (9): 1471–3. doi: 10.3201/eid1509.090330. PMC  2819870. PMID  19788817.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  4. ^ Delgado-de la Mora J, Sánchez-Montes S, Licona-Enríquez JD, Delgado-de la Mora D, Paddock CD, Beati L; et al. (2019). "Rickettsia parkeri and Candidatus Rickettsia andeanae in Tick of the Amblyomma maculatum Group, Mexico". Emerg Infect Dis. 25 (4): 836–838. doi: 10.3201/eid2504.181507. PMC  6433039. PMID  30882330.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  5. ^ Sánchez-Montes S, Ballados-González GG, Hernández-Velasco A, Zazueta-Islas HM, Solis-Cortés M, Miranda-Ortiz H; et al. (2019). "Molecular Confirmation of Rickettsia parkeri in Amblyomma ovale Ticks, Veracruz, Mexico". Emerg Infect Dis. 25 (12): 2315–2317. doi: 10.3201/eid2512.190964. PMC  6874242. PMID  31742525.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  6. ^ a b Paddock CD, Sumner JW, Comer JA, Zaki SR, Goldsmith CS, Goddard J; et al. (2004). "Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States". Clin Infect Dis. 38 (6): 805–811. doi: 10.1086/381894. PMID  14999622.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  7. ^ a b c d e f g Paddock CD, Finley RW, Wright CS, Robinson HN, Schrodt BJ, Lane CC; et al. (2008). "Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever". Clin Infect Dis. 47 (9): 1188–1196. doi: 10.1086/592254. PMID  18808353.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  8. ^ a b c d e f g Silva-Ramos CR, Hidalgo M, Faccini-Martínez ÁA (2021). "Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review". Ticks Tick-Borne Dis. 12 (4): 101734. doi: 10.1016/j.ttbdis.2021.101734. PMID  33989945. S2CID  234596034.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  9. ^ Torres-Castro M, Sánchez-Montes S, Colunga-Salas P, Noh-Pech H, Reyes-Novelo E, Rodríguez-Vivas RI (2022). "Molecular confirmation of Rickettsia parkeri in humans from Southern Mexico". Zoonoses Public Health. 69 (4): 382–386. doi: 10.1111/zph.12927. PMID  35142079. S2CID  246701684.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  10. ^ Goddard J, Paddock CD (2005). "Observations on distribution and seasonal activity of the Gulf Coast tick in Mississippi". J Med Entomol. 42 (2): 176–179. doi: 10.1093/jmedent/42.2.176. PMID  15799527.
  11. ^ Iweriebor BC, Nqoro A, Obi CL (2020). "Rickettsia africae an agent of African tick bite fever in ticks collected from domestic animals in Eastern Cape, South Africa". Pathogens. 9 (8): 631. doi: 10.3390/pathogens9080631. PMC  7459594. PMID  32748891.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  12. ^ a b Wright CL, Nadolny RM, Jiang J, Richards AL, Sonenshine DE, Gaff HD; et al. (2011). "Rickettsia parkeri in Gulf Coast ticks, southeastern Virginia, USA". Emerg Infect Dis. 17 (5): 896–8. doi: 10.3201/eid1705.101836. PMC  3321792. PMID  21529406.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  13. ^ a b c Biggs HM, Behravesh CB, Bradley KK, Dahlgren FS, Drexler NA, Dumler JS; et al. (2016). "Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain Spotted Fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis - United States". MMWR Recomm Rep. 65 (2): 1–44. doi: 10.15585/mmwr.rr6502a1. PMID  27172113.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  14. ^ a b Parker RR, Kohls GM, Cox GW, Davis GE (1939). "Observations on an infectious agent from Amblyomma maculatum". Public Health Rep. 54 (32): 1482–1484. doi: 10.1086/592254. PMID  18808353.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  15. ^ Lackman DB, Bell EJ, Stoenner HG, Pickens EG (1965). "The Rocky Mountain spotted fever group of rickettsias". Health Lab Sci. 2: 135–141. PMID  14318051.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)

External links

Retrieved from " https://en.wikipedia.org/?title=Rickettsia_parkeri&oldid=1233067487#Human_infections"
From Wikipedia, the free encyclopedia

Rickettsia parkeri
Four photos showing skin problems, one of them taken through a microscope.
Rickettsia parkeri rickettsiosis skin lesions: A - eschar after tick bite on neck; B, C - papulovesicular rash on back and leg; D - micrograph of biopsy specimen
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species group: Spotted fever group
Species:
R. parkeri
Binomial name
Rickettsia parkeri
Lackman et al., 1965

Rickettsia parkeri (abbreviated R. parkeri) is a gram-negative intracellular bacterium. The organism is found in the Western Hemisphere and is transmitted via the bite of hard ticks of the genus Amblyomma. R. parkeri causes mild spotted fever disease in humans, whose most common signs and symptoms are fever, an eschar at the site of tick attachment, rash, headache, and muscle aches. Doxycycline is the most common drug used to reduce the symptoms associated with disease.

Biology

R. parkeri is classified in the spotted fever group of the genus Rickettsia. [1] [2] Genetically, its close relatives include R. africae, R. sibirica, R. conorii, R. rickettsii, R. peacockii, and R. honei. [1]

The organism has been isolated from numerous species of ticks in the genus Amblyomma: A. americanum in the United States; A. aureolatum in Brazil; A. maculatum in Mexico, Peru, and the United States; A. nodosum in Brazil; A. ovale in Brazil and Mexico; A. parvitarsum in Argentina and Chile; A. tigrinum in Argentina, Bolivia, Brazil, and Uruguay; and A. triste in Argentina, Brazil, the United States, and Uruguay. [2] [3] [4] [5] Different ticks may carry different strains of the organism. R. parkeri sensu stricto ("in the strict sense") is found in A. maculatum and A. triste; R. parkeri strain NOD, in A. nodosum; R. parkeri strain Parvitarsum, in A. parvitarsum; and R. parkeri strain Atlantic rainforest, in A. aureolatum and A. ovale. [2]

Human infections

The first report of a confirmed human case of infection with R. parkeri was published in 2004. [6] [7] The person was infected in the state of Virginia in the United States. [6] Other confirmed or probable human cases have been reported to have acquired infection elsewhere in the United States (e.g., Arizona, Georgia, and Mississippi), as well as in Argentina, Brazil, Colombia, Mexico, and Uruguay. [8] [9] Terms used to describe human infection with R. parkeri include "American boutonneuse fever" because of its similarity to boutonneuse fever caused by Rickettsia conorii; [10] " American tick bite fever" because of its similarity to African tick bite fever caused by Rickettsia africae; [11] "Tidewater spotted fever," after the Tidewater region in the eastern United States; [12] and "Rickettsia parkeri rickettsiosis" or "R. parkeri rickettsiosis." [7] [12]

Epidemiology

Of all human cases documented in the medical literature, 87% were 18-64 years of age, and most cases were male. [8] Brazil, Argentina, and the United States accounted for the majority of cases in the medical literature. [8] In the United States, most of the 40 cases reported to the Centers for Disease Control and Prevention (CDC) as of 2016 became infected between the months of July and September. [13]: 5–6 

Diagnosis

The CDC recommends polymerase chain reaction (PCR) of a biopsy or swab of an eschar, or PCR of a biopsy of a rash, for diagnosis of R. parkeri infection. [13]: 27  In addition, indirect immunofluorescence antibody (IFA) assays using paired acute and convalescent sera can be used. [13]: 27 

Clinical manifestations

A 2008 study compared 12 R. parkeri cases with 208 Rocky Mountain spotted fever cases caused by R. rickettsii. [7] Although both R. parkeri and R. rickettsii caused fever, rash, myalgia, and headache, R. parkeri caused eschars and R. rickettsii did not. [7] Furthermore, the percentage of patients hospitalized was lower for R. parkeri than for R. rickettsii (33% vs 78%), and R. parkeri led to no deaths while R. rickettsii led to death in 7% of cases. [7]

A 2021 systematic review of 32 confirmed and 45 probable cases of human infection with R. parkeri determined that 94% of the confirmed cases had fever, 91% an eschar, 72% a rash, 56% headache, and 56% myalgia, with similar percentages among the probable cases. [8] The rash was most frequently described as papular or macular. [8] Among the confirmed and probable cases, the most common treatment was doxycycline, followed by tetracycline. [8] Although 9% of all the cases were hospitalized, there was a "100% rate of clinical recovery." [8]

History

In 1939, Ralph R. Parker, director of the Rocky Mountain Laboratory, and others published a paper on "a rickettsia-like infectious agent." [7] [14] The agent, found in Amblyomma maculatum ticks collected from cows in Texas, produced mild disease in guinea pigs. [7] [14] In 1965, Lackman and others named the rickettsial organism R. parkeri after Parker. [2] [15]

References

  1. ^ a b Perlman SJ, Hunter MS, Zchori-Fein E (2006). "The emerging diversity of Rickettsia". Proc Biol Sci. 273 (1598): 2097–2106. doi: 10.1098/rspb.2006.3541. PMC  1635513. PMID  16901827.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  2. ^ a b c d Nieri-Bastos FA, Marcili A, De Sousa R, Paddock CD, Labruna MB (2018). "Phylogenetic evidence for the existence of multiple strains of Rickettsia parkeri in the New World". Appl Environ Microbiol. 84 (8): e02872–17. Bibcode: 2018ApEnM..84E2872N. doi: 10.1128/AEM.02872-17. PMC  5881050. PMID  29439989.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  3. ^ Cohen SB, Yabsley MJ, Garrison LE, Freye JD, Dunlap BG, Dunn JR; et al. (2009). "Rickettsia parkeri in Amblyomma americanum ticks, Tennessee and Georgia, USA". Emerg Infect Dis. 15 (9): 1471–3. doi: 10.3201/eid1509.090330. PMC  2819870. PMID  19788817.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  4. ^ Delgado-de la Mora J, Sánchez-Montes S, Licona-Enríquez JD, Delgado-de la Mora D, Paddock CD, Beati L; et al. (2019). "Rickettsia parkeri and Candidatus Rickettsia andeanae in Tick of the Amblyomma maculatum Group, Mexico". Emerg Infect Dis. 25 (4): 836–838. doi: 10.3201/eid2504.181507. PMC  6433039. PMID  30882330.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  5. ^ Sánchez-Montes S, Ballados-González GG, Hernández-Velasco A, Zazueta-Islas HM, Solis-Cortés M, Miranda-Ortiz H; et al. (2019). "Molecular Confirmation of Rickettsia parkeri in Amblyomma ovale Ticks, Veracruz, Mexico". Emerg Infect Dis. 25 (12): 2315–2317. doi: 10.3201/eid2512.190964. PMC  6874242. PMID  31742525.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  6. ^ a b Paddock CD, Sumner JW, Comer JA, Zaki SR, Goldsmith CS, Goddard J; et al. (2004). "Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States". Clin Infect Dis. 38 (6): 805–811. doi: 10.1086/381894. PMID  14999622.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  7. ^ a b c d e f g Paddock CD, Finley RW, Wright CS, Robinson HN, Schrodt BJ, Lane CC; et al. (2008). "Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever". Clin Infect Dis. 47 (9): 1188–1196. doi: 10.1086/592254. PMID  18808353.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  8. ^ a b c d e f g Silva-Ramos CR, Hidalgo M, Faccini-Martínez ÁA (2021). "Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review". Ticks Tick-Borne Dis. 12 (4): 101734. doi: 10.1016/j.ttbdis.2021.101734. PMID  33989945. S2CID  234596034.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  9. ^ Torres-Castro M, Sánchez-Montes S, Colunga-Salas P, Noh-Pech H, Reyes-Novelo E, Rodríguez-Vivas RI (2022). "Molecular confirmation of Rickettsia parkeri in humans from Southern Mexico". Zoonoses Public Health. 69 (4): 382–386. doi: 10.1111/zph.12927. PMID  35142079. S2CID  246701684.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  10. ^ Goddard J, Paddock CD (2005). "Observations on distribution and seasonal activity of the Gulf Coast tick in Mississippi". J Med Entomol. 42 (2): 176–179. doi: 10.1093/jmedent/42.2.176. PMID  15799527.
  11. ^ Iweriebor BC, Nqoro A, Obi CL (2020). "Rickettsia africae an agent of African tick bite fever in ticks collected from domestic animals in Eastern Cape, South Africa". Pathogens. 9 (8): 631. doi: 10.3390/pathogens9080631. PMC  7459594. PMID  32748891.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  12. ^ a b Wright CL, Nadolny RM, Jiang J, Richards AL, Sonenshine DE, Gaff HD; et al. (2011). "Rickettsia parkeri in Gulf Coast ticks, southeastern Virginia, USA". Emerg Infect Dis. 17 (5): 896–8. doi: 10.3201/eid1705.101836. PMC  3321792. PMID  21529406.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  13. ^ a b c Biggs HM, Behravesh CB, Bradley KK, Dahlgren FS, Drexler NA, Dumler JS; et al. (2016). "Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain Spotted Fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis - United States". MMWR Recomm Rep. 65 (2): 1–44. doi: 10.15585/mmwr.rr6502a1. PMID  27172113.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  14. ^ a b Parker RR, Kohls GM, Cox GW, Davis GE (1939). "Observations on an infectious agent from Amblyomma maculatum". Public Health Rep. 54 (32): 1482–1484. doi: 10.1086/592254. PMID  18808353.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
  15. ^ Lackman DB, Bell EJ, Stoenner HG, Pickens EG (1965). "The Rocky Mountain spotted fever group of rickettsias". Health Lab Sci. 2: 135–141. PMID  14318051.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)

External links

Retrieved from " https://en.wikipedia.org/?title=Rickettsia_parkeri&oldid=1233067487#Human_infections"

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