From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Rhomboid-related protein 2 is a
protein that in humans is encoded by the RHBDL2
gene .
[5]
Function
The protein encoded by this gene is a member of the
rhomboid protease family of
integral membrane proteins . This family contains proteins that are related to
Drosophila
rhomboid-1 . Members of this family are found in both
prokaryotes and
eukaryotes and are thought to function as intramembrane
serine proteases .
RHBDL2 functions as a
sheddase and is
localized to the
plasma membrane .
[6] Known substrates of RHBDL2 include
thrombomodulin and
epidermal growth factor ;
[6] profiling of the substrate repertoire of RHBDL2 has identified a number of additional
type I membrane proteins substrates, including
BCAM ,
SPINT1 , and
CLCP1 .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000158315 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000043333 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)" .
^
a
b Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018).
"Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments" . The EMBO Journal . 37 (15).
doi :
10.15252/embj.201899456 .
PMC
6068445 .
PMID
29976761 .
^ Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (August 2017).
"Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis" . Scientific Reports . 7 (1): 7283.
Bibcode :
2017NatSR...7.7283J .
doi :
10.1038/s41598-017-07556-3 .
PMC
5544772 .
PMID
28779096 .
Further reading
Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M (May 2011).
"Mammalian EGF receptor activation by the rhomboid protease RHBDL2" . EMBO Reports . 12 (5): 421–7.
doi :
10.1038/embor.2011.50 .
PMC
3090019 .
PMID
21494248 .
Pascall JC, Brown KD (April 2004). "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2". Biochemical and Biophysical Research Communications . 317 (1): 244–52.
doi :
10.1016/j.bbrc.2004.03.039 .
PMID
15047175 .
Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, et al. (December 2011).
"Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing" . The Journal of Investigative Dermatology . 131 (12): 2486–94.
doi :
10.1038/jid.2011.230 .
PMID
21833011 .
Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, et al. (February 2010).
"Inherited genetic variant predisposes to aggressive but not indolent prostate cancer" . Proceedings of the National Academy of Sciences of the United States of America . 107 (5): 2136–40.
Bibcode :
2010PNAS..107.2136X .
doi :
10.1073/pnas.0914061107 .
PMC
2836698 .
PMID
20080650 .
Urban S, Freeman M (June 2003).
"Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain" . Molecular Cell . 11 (6): 1425–34.
doi :
10.1016/s1097-2765(03)00181-3 .
PMID
12820957 .
Urban S, Lee JR, Freeman M (October 2001).
"Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases" . Cell . 107 (2): 173–82.
doi :
10.1016/s0092-8674(01)00525-6 .
PMID
11672525 .
S2CID
9026083 .
Lei X, Li YM (December 2009). "The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity". Journal of Molecular Biology . 394 (5): 815–25.
doi :
10.1016/j.jmb.2009.10.025 .
PMID
19850051 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .