From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ras homolog gene family, member B , also known as RHOB , is a
protein which in humans is encoded by the RHOB
gene .
[5]
[6]
RHOB is a member of the
Rho GTP-binding protein family.
[7]
Interactions
RHOB has been shown to
interact with
CIT ,
[8]
ARHGEF3 ,
[9]
ARHGDIG
[10] and
RHPN2 .
[11]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000143878 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000054364 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: RHOB ras homolog gene family, member B" .
^ Chardin P, Madaule P, Tavitian A (March 1988).
"Coding sequence of human rho cDNAs clone 6 and clone 9" . Nucleic Acids Research . 16 (6): 2717.
doi :
10.1093/nar/16.6.2717 .
PMC
336400 .
PMID
3283705 .
^ Wennerberg K, Der CJ (March 2004).
"Rho-family GTPases: it's not only Rac and Rho (and I like it)" . Journal of Cell Science . 117 (Pt 8): 1301–12.
doi :
10.1242/jcs.01118 .
PMID
15020670 .
^ Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (December 1995).
"A novel partner for the GTP-bound forms of rho and rac" . FEBS Letters . 377 (2): 243–8.
doi :
10.1016/0014-5793(95)01351-2 .
PMID
8543060 .
^ Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002).
"XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC" . The Journal of Biological Chemistry . 277 (45): 42964–72.
doi :
10.1074/jbc.M207401200 .
PMID
12221096 .
^ Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996).
"RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" . The Journal of Biological Chemistry . 271 (48): 30366–74.
doi :
10.1074/jbc.271.48.30366 .
PMID
8939998 .
^ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002).
"Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF) . European Journal of Biochemistry . 269 (24): 6241–9.
doi :
10.1046/j.1432-1033.2002.03343.x .
PMID
12473120 .
S2CID
23901713 .
Further reading
Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE (January 2011).
"RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice" . The American Journal of Pathology . 178 (1): 245–52.
doi :
10.1016/j.ajpath.2010.11.040 .
PMC
3069827 .
PMID
21224061 .
Casey PJ, Seabra MC (March 1996).
"Protein prenyltransferases" . The Journal of Biological Chemistry . 271 (10): 5289–92.
doi :
10.1074/jbc.271.10.5289 .
PMID
8621375 .
Adamson P, Marshall CJ, Hall A, Tilbrook PA (October 1992).
"Post-translational modifications of p21rho proteins" . The Journal of Biological Chemistry . 267 (28): 20033–8.
doi :
10.1016/S0021-9258(19)88661-1 .
PMID
1400319 .
Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K (February 1990). "Chromosome localization of human ARH genes, a ras-related gene family". Genomics . 6 (2): 197–203.
doi :
10.1016/0888-7543(90)90557-B .
PMID
2407642 .
Chardin P, Madaule P, Tavitian A (March 1988).
"Coding sequence of human rho cDNAs clone 6 and clone 9" . Nucleic Acids Research . 16 (6): 2717.
doi :
10.1093/nar/16.6.2717 .
PMC
336400 .
PMID
3283705 .
Madaule P, Axel R (May 1985). "A novel ras-related gene family". Cell . 41 (1): 31–40.
doi :
10.1016/0092-8674(85)90058-3 .
PMID
3888408 .
S2CID
32708060 .
Robertson D, Paterson HF, Adamson P, Hall A, Monaghan P (May 1995).
"Ultrastructural localization of ras-related proteins using epitope-tagged plasmids" . The Journal of Histochemistry and Cytochemistry . 43 (5): 471–80.
doi :
10.1177/43.5.7537292 .
PMID
7537292 .
Armstrong SA, Hannah VC, Goldstein JL, Brown MS (April 1995).
"CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB" . The Journal of Biological Chemistry . 270 (14): 7864–8.
doi :
10.1074/jbc.270.14.7864 .
PMID
7713879 .
Bonaldo MF, Lennon G, Soares MB (September 1996).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996).
"RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" . The Journal of Biological Chemistry . 271 (48): 30366–74.
doi :
10.1074/jbc.271.48.30366 .
PMID
8939998 .
Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ (February 1998).
"PRK1 is targeted to endosomes by the small GTPase, RhoB" . The Journal of Biological Chemistry . 273 (9): 4811–4.
doi :
10.1074/jbc.273.9.4811 .
PMID
9478917 .
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998).
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76.
doi :
10.1093/dnares/5.3.169 .
PMID
9734811 .
Liu JP, Jessell TM (December 1998). "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube". Development . 125 (24): 5055–67.
doi :
10.1242/dev.125.24.5055 .
PMID
9811589 .
Gampel A, Parker PJ, Mellor H (September 1999).
"Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB" . Current Biology . 9 (17): 955–8.
Bibcode :
1999CBio....9..955G .
doi :
10.1016/S0960-9822(99)80422-9 .
PMID
10508588 .
S2CID
9616910 .
Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W (January 2000).
"The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly" . Cell Death and Differentiation . 7 (1): 25–36.
doi :
10.1038/sj.cdd.4400616 .
PMID
10713718 .
Liu Ax, Du W, Liu JP, Jessell TM, Prendergast GC (August 2000).
"RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors" . Molecular and Cellular Biology . 20 (16): 6105–13.
doi :
10.1128/MCB.20.16.6105-6113.2000 .
PMC
86086 .
PMID
10913192 .
Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (January 2001).
"Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding" . The Journal of Cell Biology . 152 (1): 111–26.
doi :
10.1083/jcb.152.1.111 .
PMC
2193662 .
PMID
11149925 .
Cerniglia GJ, Bernhard EJ, Prendergast GC (May 2001).
"RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage" . Proceedings of the National Academy of Sciences of the United States of America . 98 (11): 6192–7.
Bibcode :
2001PNAS...98.6192L .
doi :
10.1073/pnas.111137198 .
PMC
33444 .
PMID
11353846 .
Diviani D, Soderling J, Scott JD (November 2001).
"AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation" . The Journal of Biological Chemistry . 276 (47): 44247–57.
doi :
10.1074/jbc.M106629200 .
PMID
11546812 .
Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Muñoz-Antonia T (March 2002).
"RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1" . The Journal of Biological Chemistry . 277 (10): 8500–7.
doi :
10.1074/jbc.M104367200 .
PMID
11741970 .