Macacine gammaherpesvirus 4 | |
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Virus classification
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(unranked): | Virus |
Realm: | Duplodnaviria |
Kingdom: | Heunggongvirae |
Phylum: | Peploviricota |
Class: | Herviviricetes |
Order: | Herpesvirales |
Family: | Orthoherpesviridae |
Genus: | Lymphocryptovirus |
Species: | Macacine gammaherpesvirus 4
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Synonyms | |
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Macacine gammaherpesvirus 4 (McHV-4), commonly known as rhesus lymphocryptovirus (RLV), is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales. [1]
In nature, Macacine gammaherpesvirus 4 infects rhesus macaques (Macaca mulatta).
Its genetic structure has been fully sequenced and found to be highly homologous with that of Human gammaherpesvirus 4, commonly known as Epstein-Barr virus, at 65%. The structural proteins are highly conserved, while genes expressed during Human gammaherpesvirus 4 latent infection are much less well conserved. Even in cases where genes have low homology, the Macacine gammaherpesvirus 4 infection genes are functionally interchangeable with Human gammaherpesvirus 4 genes. [2]
Macacine gammaherpesvirus 4 infection in rhesus monkeys resembles Human gammaherpesvirus 4 infection in humans in several respects:
These features make the rhesus lymphocryptovirus potentially useful for studying the pathogenesis, prevention, and treatment of Human gammaherpesvirus 4 infection and associated oncogenesis. [3]
Macacine gammaherpesvirus 4 | |
---|---|
Virus classification
![]() | |
(unranked): | Virus |
Realm: | Duplodnaviria |
Kingdom: | Heunggongvirae |
Phylum: | Peploviricota |
Class: | Herviviricetes |
Order: | Herpesvirales |
Family: | Orthoherpesviridae |
Genus: | Lymphocryptovirus |
Species: | Macacine gammaherpesvirus 4
|
Synonyms | |
|
Macacine gammaherpesvirus 4 (McHV-4), commonly known as rhesus lymphocryptovirus (RLV), is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales. [1]
In nature, Macacine gammaherpesvirus 4 infects rhesus macaques (Macaca mulatta).
Its genetic structure has been fully sequenced and found to be highly homologous with that of Human gammaherpesvirus 4, commonly known as Epstein-Barr virus, at 65%. The structural proteins are highly conserved, while genes expressed during Human gammaherpesvirus 4 latent infection are much less well conserved. Even in cases where genes have low homology, the Macacine gammaherpesvirus 4 infection genes are functionally interchangeable with Human gammaherpesvirus 4 genes. [2]
Macacine gammaherpesvirus 4 infection in rhesus monkeys resembles Human gammaherpesvirus 4 infection in humans in several respects:
These features make the rhesus lymphocryptovirus potentially useful for studying the pathogenesis, prevention, and treatment of Human gammaherpesvirus 4 infection and associated oncogenesis. [3]