The repeatome can be defined as the complement of repeated sequences in a genome. The eukaryotic repeatomes typically comprise variable amounts of multiple components including transposable elements (TEs) and endogenous viruses, simple sequence repeats, segmental duplications, ribosomal DNA and other ribozymes, multi-copy gene families, pseudogenes, as well as highly conserved and repeated protein domains. Because of their relative high duplication rate as compared to other genomic components, TEs are typically predominant contributors to eukaryotic repeatomes and the product of their decay is thought to be a major source of genomic dark matter. [1] [2] [3]
See also
References
- ^ Orgel, Crick (1980). "Selfish DNA: the ultimate parasite". Nature. 284 (5757): 604–7. Bibcode: 1980Natur.284..604O. doi: 10.1038/284604a0. PMID 7366731. S2CID 4233826.
- ^ Maumus, Quesneville (April 2014). "Deep Investigation of Arabidopsis thaliana Junk DNA Reveals a Continuum between Repetitive Elements and Genomic Dark Matter". PLOS ONE. 9 (4): e94101. Bibcode: 2014PLoSO...994101M. doi: 10.1371/journal.pone.0094101. PMC 3978025. PMID 24709859.
- ^ Hannan, Anthony J. (2012). "Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility". Adv. Exp. Med. Biol. 769: 1–9. PMID 23560301.
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The repeatome can be defined as the complement of repeated sequences in a genome. The eukaryotic repeatomes typically comprise variable amounts of multiple components including transposable elements (TEs) and endogenous viruses, simple sequence repeats, segmental duplications, ribosomal DNA and other ribozymes, multi-copy gene families, pseudogenes, as well as highly conserved and repeated protein domains. Because of their relative high duplication rate as compared to other genomic components, TEs are typically predominant contributors to eukaryotic repeatomes and the product of their decay is thought to be a major source of genomic dark matter. [1] [2] [3]
See also
References
- ^ Orgel, Crick (1980). "Selfish DNA: the ultimate parasite". Nature. 284 (5757): 604–7. Bibcode: 1980Natur.284..604O. doi: 10.1038/284604a0. PMID 7366731. S2CID 4233826.
- ^ Maumus, Quesneville (April 2014). "Deep Investigation of Arabidopsis thaliana Junk DNA Reveals a Continuum between Repetitive Elements and Genomic Dark Matter". PLOS ONE. 9 (4): e94101. Bibcode: 2014PLoSO...994101M. doi: 10.1371/journal.pone.0094101. PMC 3978025. PMID 24709859.
- ^ Hannan, Anthony J. (2012). "Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility". Adv. Exp. Med. Biol. 769: 1–9. PMID 23560301.
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