RASA2
Identifiers
Aliases	RASA2, GAP1M, RAS p21 protein activator 2
External IDs	OMIM: 601589; MGI: 2149960; HomoloGene: 4745; GeneCards: RASA2; OMA: RASA2 - orthologs
Gene location ( Human) Chr. Chromosome 3 (human) [1] Band 3q23 Start 141,487,027 bp [1] End 141,615,344 bp [1]
Gene location ( Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.3 Start 96,539,300 bp [2] End 96,631,617 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery trabecular bone nipple tibia visceral pleura Brodmann area 23 parietal pleura Achilles tendon oral cavity germinal epithelium Top expressed in secondary oocyte median eminence primary motor cortex lymph node olfactory bulb renal corpuscle mammillary body conjunctival fornix medullary collecting duct arcuate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding GTPase activator activity phospholipid binding Cellular component cytoplasm cytosol intrinsic component of the cytoplasmic side of the plasma membrane perinuclear region of cytoplasm Biological process intracellular signal transduction regulation of GTPase activity MAPK cascade positive regulation of GTPase activity signal transduction negative regulation of Ras protein signal transduction Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5922 114713 Ensembl ENSG00000155903 ENSMUSG00000032413 UniProt Q15283 P58069 RefSeq (mRNA) NM_001303245 NM_001303246 NM_006506 NM_053268 RefSeq (protein) NP_001290174 NP_001290175 NP_006497 NP_444498 Location (UCSC) Chr 3: 141.49 – 141.62 Mb Chr 9: 96.54 – 96.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. ^[5]

Function

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

• v
• t
• e