Radixin is a
cytoskeletal protein that may be important in linking
actin to the plasma membrane. It is highly similar in sequence to both
ezrin and
moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a
pseudogene (RDXP2) was assigned to
Xp21.3. Another pseudogene that seemed to lack
introns (RDXP1) was mapped to 11p by Southern and PCR analyses.[7]
Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1992). "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites". J. Cell Sci. 103 (1): 131–43.
doi:
10.1242/jcs.103.1.131.
PMID1429901.
Bhartur SG, Goldenring JR (1998). "Mapping of ezrin dimerization using yeast two-hybrid screening". Biochem. Biophys. Res. Commun. 243 (3): 874–7.
doi:
10.1006/bbrc.1998.8196.
PMID9501018.
Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene. 16 (25): 3279–84.
doi:
10.1038/sj.onc.1201874.
PMID9681826.
S2CID21445282.
Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A (2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7.
doi:
10.1038/35010550.
PMID10806479.
S2CID25353057.
Hamada K, Shimizu T, Matsui T, Tsukita S, Tsukita S, Hakoshima T (2001). "Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr. D. 57 (Pt 6): 891–2.
Bibcode:
2001AcCrD..57..891H.
doi:
10.1107/S0907444901005716.
PMID11375520.
Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S (2002). "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes". Nat. Genet. 31 (3): 320–5.
doi:
10.1038/ng905.
PMID12068294.
S2CID24961102.
Radixin is a
cytoskeletal protein that may be important in linking
actin to the plasma membrane. It is highly similar in sequence to both
ezrin and
moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a
pseudogene (RDXP2) was assigned to
Xp21.3. Another pseudogene that seemed to lack
introns (RDXP1) was mapped to 11p by Southern and PCR analyses.[7]
Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1992). "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites". J. Cell Sci. 103 (1): 131–43.
doi:
10.1242/jcs.103.1.131.
PMID1429901.
Bhartur SG, Goldenring JR (1998). "Mapping of ezrin dimerization using yeast two-hybrid screening". Biochem. Biophys. Res. Commun. 243 (3): 874–7.
doi:
10.1006/bbrc.1998.8196.
PMID9501018.
Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene. 16 (25): 3279–84.
doi:
10.1038/sj.onc.1201874.
PMID9681826.
S2CID21445282.
Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A (2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7.
doi:
10.1038/35010550.
PMID10806479.
S2CID25353057.
Hamada K, Shimizu T, Matsui T, Tsukita S, Tsukita S, Hakoshima T (2001). "Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr. D. 57 (Pt 6): 891–2.
Bibcode:
2001AcCrD..57..891H.
doi:
10.1107/S0907444901005716.
PMID11375520.
Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S (2002). "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes". Nat. Genet. 31 (3): 320–5.
doi:
10.1038/ng905.
PMID12068294.
S2CID24961102.