| RTL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2685221; HomoloGene: 19397; GeneCards: RTL3; OMA: RTL3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. [5]
Function
This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif. [6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes. [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179300 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047686 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
- ^ a b Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi: 10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |
| RTL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2685221; HomoloGene: 19397; GeneCards: RTL3; OMA: RTL3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. [5]
Function
This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif. [6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes. [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179300 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047686 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
- ^ a b Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi: 10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |