Identifiers | |
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Chemical and physical data | |
Formula | C29H32F3N3O5 |
Molar mass | 559.586 g·mol−1 |
3D model ( JSmol) | |
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RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine. [1] [2] [3]
Identifiers | |
---|---|
| |
Chemical and physical data | |
Formula | C29H32F3N3O5 |
Molar mass | 559.586 g·mol−1 |
3D model ( JSmol) | |
|
RTIOX-276 is an orexin antagonist. RTIOX-276 binds selectively to the orexin 1 receptor (KE = 8.5nM) and lacks significant affinity for the orexin 2 receptor (KE = > 10,000nM). RTIOX-276 may have therapeutic utility for the treatment of cocaine addiction. In conditioned place preference studies, RTIOX-276 attenuated the development of place preference in mice exposed to cocaine. [1] [2] [3]