RPL22L1

RPL22L1
Identifiers
Aliases	RPL22L1, ribosomal protein L22 like 1
External IDs	MGI: 1915278; HomoloGene: 134069; GeneCards: RPL22L1; OMA: RPL22L1 - orthologs
Gene location ( Human)
Chr.	Chromosome 3 (human)
End	170,870,208 bp
Gene location ( Mouse)
Chr.	Chromosome 3 (mouse)
End	28,861,573 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; body of pancreas; ; skin of arm; ; appendix; ; gums; ; gingival epithelium; ; ventricular zone; ; lymph node; ; spleen; ; skin of abdomen;
	Top expressed in
	embryo; ; epiblast; ; embryo; ; ventricular zone; ; lens; ; uterus; ; pancreas; ; hypothalamus; ; ileum; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	cytosolic large ribosomal subunit; ribosome; intracellular anatomical structure;
Biological process	cytoplasmic translation; protein biosynthesis;
	Sources: Amigo / QuickGO
Orthologs
	200916
	68028
	ENSG00000163584
	ENSMUSG00000039221
	Q6P5R6
	Q9D7S7
	NM_001099645; NM_001320451
	NM_026517; NM_001347226
	NP_001093115; NP_001307380
	NP_001334155; NP_080793
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein L22 like 1 (RPL22L1), or eL22L1, is a protein that in humans is encoded by the RPL22L1 gene. ^[5]

Function

eL22L1 is a ribosomal protein paralog of the eL22 protein of the 60S ribosomal subunit. This paralog is divergent from the normal copy, and is expressed when the normal copy is deleted from mice.^[6] This compensation implies a ribosome function similar to the normal copy, though eL22L1 has also been implicates in other extraribosomal roles including pre-mRNA splicing regulation in zebrafish.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163584 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039221 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ribosomal protein L22 like 1". Retrieved 2019-12-03.
^ O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, et al. (2013-08-22). Copenhaver GP (ed.). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLOS Genetics. 9 (8). Public Library of Science (PLoS): e1003708. doi: 10.1371/journal.pgen.1003708. PMC 3750023. PMID 23990801.
^ Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, et al. (January 2017). "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports. 18 (2). Elsevier BV: 545–556. doi: 10.1016/j.celrep.2016.12.034. PMC 5234864. PMID 28076796.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163584 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039221 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ribosomal protein L22 like 1". Retrieved 2019-12-03.

[OLeary_Schreiber_Zhang_Duc_p=e1003708-6] O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, et al. (2013-08-22). Copenhaver GP (ed.). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLOS Genetics. 9 (8). Public Library of Science (PLoS): e1003708. doi: 10.1371/journal.pgen.1003708. PMC 3750023. PMID 23990801.

[Zhang_O’Leary_Peri_Wang_2017_pp._545–556-7] Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, et al. (January 2017). "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports. 18 (2). Elsevier BV: 545–556. doi: 10.1016/j.celrep.2016.12.034. PMC 5234864. PMID 28076796.

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