RING finger protein 4 is a
protein that in humans is encoded by the RNF4gene.[5][6]
The protein encoded by this gene contains a
RING finger domain and acts as a
transcription factor. This protein has been shown to interact with, and inhibit the activity of,
TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/
PATZ1 is found to interact with this protein, and thus reduce the enhancement of
androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in
spermatogenesis.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65.
doi:
10.1006/geno.1997.5105.
PMID9479498.
Pero R, Lembo F, Chieffi P, Del Pozzo G, Fedele M, Fusco A, Bruni CB, Chiariotti L (Sep 2003). "Translational regulation of a novel testis-specific RNF4 transcript". Molecular Reproduction and Development. 66 (1): 1–7.
doi:
10.1002/mrd.10322.
PMID12874792.
S2CID6206480.
RING finger protein 4 is a
protein that in humans is encoded by the RNF4gene.[5][6]
The protein encoded by this gene contains a
RING finger domain and acts as a
transcription factor. This protein has been shown to interact with, and inhibit the activity of,
TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/
PATZ1 is found to interact with this protein, and thus reduce the enhancement of
androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in
spermatogenesis.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65.
doi:
10.1006/geno.1997.5105.
PMID9479498.
Pero R, Lembo F, Chieffi P, Del Pozzo G, Fedele M, Fusco A, Bruni CB, Chiariotti L (Sep 2003). "Translational regulation of a novel testis-specific RNF4 transcript". Molecular Reproduction and Development. 66 (1): 1–7.
doi:
10.1002/mrd.10322.
PMID12874792.
S2CID6206480.