RNF24

RNF24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EP4
Identifiers
Aliases	RNF24, G1L, ring finger protein 24
External IDs	OMIM: 612489; MGI: 1261771; HomoloGene: 5223; GeneCards: RNF24; OMA: RNF24 - orthologs
Gene location ( Human)
Chr.	Chromosome 20 (human)
End	4,015,558 bp
Gene location ( Mouse)
Chr.	Chromosome 2 (mouse)
End	131,194,812 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; blood; ; pericardium; ; cartilage tissue; ; nipple; ; renal medulla; ; stromal cell of endometrium; ; trigeminal ganglion; ; endothelial cell; ; Descending thoracic aorta;
	Top expressed in
	zygote; ; secondary oocyte; ; otolith organ; ; utricle; ; human kidney; ; seminiferous tubule; ; ganglionic eminence; ; hand; ; right kidney; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; ubiquitin protein ligase activity; metal ion binding;
Cellular component	integral component of membrane; Golgi membrane; membrane; Golgi apparatus; endomembrane system;
Biological process	protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination;
	Sources: Amigo / QuickGO
Orthologs
	11237
	51902
	ENSG00000101236
	ENSMUSG00000048911
	Q9Y225
	Q8BGI1
	NM_001134337; NM_001134338; NM_007219; NM_001321749; NM_016502
	NM_178607
	NP_001127809; NP_001127810; NP_001308678; NP_009150
	NP_848722
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger protein 24 is a protein that in humans is encoded by the RNF24 gene.^[5]^[6]

RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel ( TRPC) family members and is involved in regulation of intracellular trafficking of TRPCs.^[6] In addition, RNF24 contains similarity to the Drosophila goliath protein and thus may function as a transcription factor.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101236 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ring finger protein 24".
^ ^a ^b Lussier MP, Lepage PK, Bousquet SM, Boulay G (May 2008). "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC". Cell Calcium. 43 (5): 432–43. doi: 10.1016/j.ceca.2007.07.009. PMID 17850865.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi: 10.1101/gr.140200. PMC 310934. PMID 11042152.
Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode: 2001Natur.414..865D. doi: 10.1038/414865a. PMID 11780052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101236 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ring finger protein 24".

[pmid17850865-6] Lussier MP, Lepage PK, Bousquet SM, Boulay G (May 2008). "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC". Cell Calcium. 43 (5): 432–43. doi: 10.1016/j.ceca.2007.07.009. PMID 17850865.

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