RNF144A is an
E3 ubiquitin ligase belonging to the RING-between RING (RBR) family of
ubiquitinligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases.[5][6][7] RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins.[8][9][10] The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.[11][12]
Current known
substrates of RNF144A targeted for degradation are proteins involved in
DNA repair, heatshock/chaperone function and signalling, consistent with the predominant association of this protein with cancer, and include (
DNA-PKcs),
PARP1,
HSPA2,
BMI1, and
RAF1.[17][18][19][20][21]
RNF144A is an
E3 ubiquitin ligase belonging to the RING-between RING (RBR) family of
ubiquitinligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases.[5][6][7] RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins.[8][9][10] The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.[11][12]
Current known
substrates of RNF144A targeted for degradation are proteins involved in
DNA repair, heatshock/chaperone function and signalling, consistent with the predominant association of this protein with cancer, and include (
DNA-PKcs),
PARP1,
HSPA2,
BMI1, and
RAF1.[17][18][19][20][21]