RING finger protein 139, also known as TRC8, is a
protein that in humans is encoded by the RNF139gene.[5][6]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the
endoplasmic reticulum, and has been shown to possess
ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary
renal and non-medullary
thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein
VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of
tumor suppressor CDKN1B/P27KIP].[6]
Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene". Oncogene. 26 (16): 2263–71.
doi:
10.1038/sj.onc.1210017.
PMID17016439.
S2CID12979173.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16.
doi:
10.1038/sj.onc.1205437.
PMID12032852.
S2CID9964634.
RING finger protein 139, also known as TRC8, is a
protein that in humans is encoded by the RNF139gene.[5][6]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the
endoplasmic reticulum, and has been shown to possess
ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary
renal and non-medullary
thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein
VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of
tumor suppressor CDKN1B/P27KIP].[6]
Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene". Oncogene. 26 (16): 2263–71.
doi:
10.1038/sj.onc.1210017.
PMID17016439.
S2CID12979173.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16.
doi:
10.1038/sj.onc.1205437.
PMID12032852.
S2CID9964634.