GTP-binding protein Rit2 is a
protein that in humans is encoded by the RIT2gene.[5][6][7]
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][7]
RIT2 has been associated with Parkinson's disease in two large genetic studies.[8][9] An gene expression study of postmortem brain has suggested RIT2 interacts with
interferon-γ signalling.[10]
^Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14.
doi:
10.1038/sj.onc.1206635.
PMID12934100.
S2CID670567.
Further reading
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19.
doi:
10.1006/abbi.1999.1448.
PMID10545207.
Hoshino M, Nakamura S (July 2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation". Biochemical and Biophysical Research Communications. 295 (3): 651–6.
doi:
10.1016/S0006-291X(02)00731-3.
PMID12099688.
Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14.
doi:
10.1038/sj.onc.1206635.
PMID12934100.
S2CID670567.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID16189514.
S2CID4427026.
GTP-binding protein Rit2 is a
protein that in humans is encoded by the RIT2gene.[5][6][7]
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][7]
RIT2 has been associated with Parkinson's disease in two large genetic studies.[8][9] An gene expression study of postmortem brain has suggested RIT2 interacts with
interferon-γ signalling.[10]
^Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14.
doi:
10.1038/sj.onc.1206635.
PMID12934100.
S2CID670567.
Further reading
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19.
doi:
10.1006/abbi.1999.1448.
PMID10545207.
Hoshino M, Nakamura S (July 2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation". Biochemical and Biophysical Research Communications. 295 (3): 651–6.
doi:
10.1016/S0006-291X(02)00731-3.
PMID12099688.
Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14.
doi:
10.1038/sj.onc.1206635.
PMID12934100.
S2CID670567.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID16189514.
S2CID4427026.