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Antimicrobial peptides secreted by intestinal immune and epithelial cells
Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a
protein that in humans is encoded by the REG3G
gene .
[5]
[6]
[7]
[8]
Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of
toll-like receptors (TLRs) by
pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets
Gram-positive bacteria because it binds to their surface
peptidoglycan layer. It is one of several antimicrobial peptides produced by
paneth cells .
[9]
Notes and references
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000143954 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000030017 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
^ Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene . 340 (1): 161–70.
doi :
10.1016/j.gene.2004.06.010 .
PMID
15556304 .
^ Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005).
"PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication" (PDF) . Biochim. Biophys. Acta . 1727 (3): 177–87.
doi :
10.1016/j.bbaexp.2005.01.011 .
PMID
15777617 .
S2CID
24552883 .
^
"Entrez Gene: REG3G regenerating islet-derived 3 gamma" .
^ Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol . 10 (2): 131–44.
doi :
10.1038/nri2707 .
PMID
20098461 .
S2CID
21789611 .
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