Calcipressin-1, which shares a similar function to Calcipressin-3. Both repress calcineurin.
Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the
Calcipressin family of proteins.[5][6]
Expression
RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the
esophagus.[7]
Orthologs
RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).[8]
Clinical Significance
Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.[9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63.
doi:
10.1006/geno.2000.6127.
PMID10756093.
Facchin F, Canaider S, Vitale L, et al. (2008). "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms". Gene. 407 (1–2): 159–68.
doi:
10.1016/j.gene.2007.10.006.
PMID18022329.
Canaider S, Facchin F, Griffoni C, et al. (2006). "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)". Gene. 372: 128–36.
doi:
10.1016/j.gene.2005.12.029.
hdl:11586/196835.
PMID16516408.
Calcipressin-1, which shares a similar function to Calcipressin-3. Both repress calcineurin.
Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the
Calcipressin family of proteins.[5][6]
Expression
RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the
esophagus.[7]
Orthologs
RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).[8]
Clinical Significance
Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.[9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63.
doi:
10.1006/geno.2000.6127.
PMID10756093.
Facchin F, Canaider S, Vitale L, et al. (2008). "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms". Gene. 407 (1–2): 159–68.
doi:
10.1016/j.gene.2007.10.006.
PMID18022329.
Canaider S, Facchin F, Griffoni C, et al. (2006). "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)". Gene. 372: 128–36.
doi:
10.1016/j.gene.2005.12.029.
hdl:11586/196835.
PMID16516408.