From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Histone-binding protein RBBP7 is a
protein that in humans is encoded by the RBBP7
gene .
[5]
Function
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of
WD-repeat proteins. It is found among several proteins that binds directly to
retinoblastoma protein , which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
[6]
Interactions
RBBP7 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000102054 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031353 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Qian YW,
Lee EY (Dec 1995).
"Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast" . J Biol Chem . 270 (43): 25507–25513.
doi :
10.1074/jbc.270.43.25507 .
PMID
7503932 .
^
"Entrez Gene: RBBP7 retinoblastoma binding protein 7" .
^
a
b Yarden RI, Brody LC (April 1999).
"BRCA1 interacts with components of the histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4983–8.
Bibcode :
1999PNAS...96.4983Y .
doi :
10.1073/pnas.96.9.4983 .
PMC
21803 .
PMID
10220405 .
^ Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (June 2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1". Biochem. Biophys. Res. Commun . 284 (2): 507–14.
doi :
10.1006/bbrc.2001.5003 .
PMID
11394910 .
^ Yarden RI, Brody LC (2001).
"Identification of proteins that interact with BRCA1 by Far-Western library screening" . J. Cell. Biochem . 83 (4): 521–31.
doi :
10.1002/jcb.1257 .
PMID
11746496 .
S2CID
29703139 .
^ Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002).
"Identification and functional characterization of the p66/p68 components of the MeCP1 complex" . Mol. Cell. Biol . 22 (2): 536–46.
doi :
10.1128/mcb.22.2.536-546.2002 .
PMC
139742 .
PMID
11756549 .
^
a
b Yao YL, Yang WM (October 2003).
"The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity" . J. Biol. Chem . 278 (43): 42560–8.
doi :
10.1074/jbc.M302955200 .
PMID
12920132 .
^ Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet . 23 (1): 58–61.
doi :
10.1038/12659 .
hdl :
1842/684 .
PMID
10471499 .
S2CID
6147725 .
^
a
b
c Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999).
"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes Dev . 13 (15): 1924–35.
doi :
10.1101/gad.13.15.1924 .
PMC
316920 .
PMID
10444591 .
^ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997).
"Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–64.
doi :
10.1016/s0092-8674(00)80216-0 .
PMID
9150135 .
^
a
b Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (June 1998).
"SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex" . Mol. Cell . 1 (7): 1021–31.
doi :
10.1016/s1097-2765(00)80102-1 .
PMID
9651585 .
^
a
b Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002).
"Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Mol. Cell. Biol . 22 (3): 835–48.
doi :
10.1128/mcb.22.3.835-848.2002 .
PMC
133546 .
PMID
11784859 .
Further reading
Huang S, Lee WH, Lee EY (1991). "A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product". Nature . 350 (6314): 160–162.
Bibcode :
1991Natur.350..160H .
doi :
10.1038/350160a0 .
PMID
2005966 .
S2CID
4345233 .
Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997).
"Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–364.
doi :
10.1016/S0092-8674(00)80216-0 .
PMID
9150135 .
Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998).
"Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase" . Curr. Biol . 8 (2): 96–108.
Bibcode :
1998CBio....8...96V .
doi :
10.1016/S0960-9822(98)70040-5 .
PMID
9427644 .
S2CID
201273 .
Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (1998).
"SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex" . Mol. Cell . 1 (7): 1021–1031.
doi :
10.1016/S1097-2765(00)80102-1 .
PMID
9651585 .
Guan LS, Rauchman M, Wang ZY (1998).
"Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition" . J. Biol. Chem . 273 (42): 27047–27050.
doi :
10.1074/jbc.273.42.27047 .
PMID
9765217 .
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998).
"The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities" . Cell . 95 (2): 279–289.
doi :
10.1016/S0092-8674(00)81758-4 .
PMID
9790534 .
S2CID
18786866 .
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature . 395 (6705): 917–921.
Bibcode :
1998Natur.395..917T .
doi :
10.1038/27699 .
PMID
9804427 .
S2CID
4355885 .
Yarden RI, Brody LC (1999).
"BRCA1 interacts with components of the histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4983–4988.
Bibcode :
1999PNAS...96.4983Y .
doi :
10.1073/pnas.96.9.4983 .
PMC
21803 .
PMID
10220405 .
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999).
"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes Dev . 13 (15): 1924–1935.
doi :
10.1101/gad.13.15.1924 .
PMC
316920 .
PMID
10444591 .
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nat. Genet . 23 (1): 62–66.
doi :
10.1038/12664 .
PMID
10471500 .
S2CID
52868103 .
Zhang Q, Vo N, Goodman RH (2000).
"Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB" . Mol. Cell. Biol . 20 (14): 4970–4978.
doi :
10.1128/MCB.20.14.4970-4978.2000 .
PMC
85947 .
PMID
10866654 .
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001).
"Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . J. Biol. Chem . 276 (9): 6817–6824.
doi :
10.1074/jbc.M007372200 .
PMID
11102443 .
Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (2001).
"Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex" . J. Biol. Chem . 276 (12): 8734–8739.
doi :
10.1074/jbc.M007664200 .
PMID
11118440 .
Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1". Biochem. Biophys. Res. Commun . 284 (2): 507–514.
doi :
10.1006/bbrc.2001.5003 .
PMID
11394910 .
Yarden RI, Brody LC (2002).
"Identification of proteins that interact with BRCA1 by Far-Western library screening" . J. Cell. Biochem . 83 (4): 521–531.
doi :
10.1002/jcb.1257 .
PMID
11746496 .
S2CID
29703139 .
Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (2002).
"Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Mol. Cell. Biol . 22 (3): 835–848.
doi :
10.1128/MCB.22.3.835-848.2002 .
PMC
133546 .
PMID
11784859 .
Vaute O, Nicolas E, Vandel L, Trouche D (2002).
"Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases" . Nucleic Acids Res . 30 (2): 475–481.
doi :
10.1093/nar/30.2.475 .
PMC
99834 .
PMID
11788710 .
Saito M, Ishikawa F (2002).
"The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2" . J. Biol. Chem . 277 (38): 35434–35439.
doi :
10.1074/jbc.M203455200 .
PMID
12124384 .
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002).
"Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein" . Genes Dev . 16 (22): 2893–2905.
doi :
10.1101/gad.1035902 .
PMC
187479 .
PMID
12435631 .