From Wikipedia, the free encyclopedia
RABGEF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RABGEF1, RABEX5, RAP1, rabex-5, RAB guanine nucleotide exchange factor 1
External IDs OMIM: 609700; MGI: 1929459; HomoloGene: 8720; GeneCards: RABGEF1; OMA: RABGEF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001287060
NM_001287061
NM_001287062
NM_014504

NM_001199059
NM_019983
NM_001359233
NM_001378873

RefSeq (protein)
Location (UCSC) Chr 7: 66.68 – 66.81 Mb Chr 5: 130.2 – 130.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene. [5] [6] [7]

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5( RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM]. [7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154710Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025340Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Dec 2002). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi: 10.1093/emboj/cdg015. PMC  140067. PMID  12505986.
  6. ^ Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O (Dec 2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37–43. doi: 10.1016/S0304-3835(00)00553-X. PMID  11098082.
  7. ^ a b "Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1".

Further reading

From Wikipedia, the free encyclopedia
RABGEF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RABGEF1, RABEX5, RAP1, rabex-5, RAB guanine nucleotide exchange factor 1
External IDs OMIM: 609700; MGI: 1929459; HomoloGene: 8720; GeneCards: RABGEF1; OMA: RABGEF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001287060
NM_001287061
NM_001287062
NM_014504

NM_001199059
NM_019983
NM_001359233
NM_001378873

RefSeq (protein)
Location (UCSC) Chr 7: 66.68 – 66.81 Mb Chr 5: 130.2 – 130.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene. [5] [6] [7]

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5( RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM]. [7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154710Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025340Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Dec 2002). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi: 10.1093/emboj/cdg015. PMC  140067. PMID  12505986.
  6. ^ Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O (Dec 2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37–43. doi: 10.1016/S0304-3835(00)00553-X. PMID  11098082.
  7. ^ a b "Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1".

Further reading


Videos

Youtube | Vimeo | Bing

Websites

Google | Yahoo | Bing

Encyclopedia

Google | Yahoo | Bing

Facebook