QSC may refer to:

Corporations

• QSC AG, a German telecommunications and DSL provider
• QSC Audio Products aka Q-SYS, a global audio, video, and control platform manufacturer based in California
• Queens Surface Corporation, a former bus company in New York City

Colleges

• Queen's School of Computing, a department of Queen's University in Kingston, Ontario, Canada
• Quirino State College, former name of Quirino State University in Quirino, Philippines

Other uses

• QSC, the IATA airport code for São Carlos Airport in Brazil
• QSC, a radiotelegraphic Q code meaning "are you a cargo vessel" when posed as a question
• qSc, a portion of the equation defining the pitching moment coefficient of an airfoil
• Quebec Superior Court, the trial-level superior court of the province of Quebec, Canada
• Queens Sports Club, a stadium in Bulawayo, Zimbabwe
• QSC&V (Quality, Service, Cleanliness & Value), a quality benchmark used by McDonald's Corporation
• QSC supercomputer (2004–2007), a supercomputer at Los Alamos National Laboratory which replaced Blue Mountain (supercomputer)

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