Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a
protein which in humans is encoded by the QKIgene.[5][6]
QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[7] They have an
HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (
KHDRBS1) and
SF1 .[8] Two more new members are
KHDRBS3[9] and
KHDRBS2.[10]
The QKI gene is implicated as being important in schizophrenia,[11][12] and QKI controls translation of many oligodendrocyte-related genes.
^Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84.
doi:
10.1016/S0168-9525(97)01269-9.
PMID9433137.
^Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75.
doi:
10.1023/A:1021246109101.
PMID12549823.
S2CID21864405.
^Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7.
doi:
10.1176/ajp.2006.163.10.1834.
PMID17012699.
Further reading
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.
Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90.
doi:
10.1002/ajmg.b.30243.
PMID16342280.
S2CID11733591.
Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". The American Journal of Psychiatry. 163 (10): 1834–7.
doi:
10.1176/ajp.2006.163.10.1834.
PMID17012699.
Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a
protein which in humans is encoded by the QKIgene.[5][6]
QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[7] They have an
HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (
KHDRBS1) and
SF1 .[8] Two more new members are
KHDRBS3[9] and
KHDRBS2.[10]
The QKI gene is implicated as being important in schizophrenia,[11][12] and QKI controls translation of many oligodendrocyte-related genes.
^Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84.
doi:
10.1016/S0168-9525(97)01269-9.
PMID9433137.
^Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75.
doi:
10.1023/A:1021246109101.
PMID12549823.
S2CID21864405.
^Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7.
doi:
10.1176/ajp.2006.163.10.1834.
PMID17012699.
Further reading
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.
Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90.
doi:
10.1002/ajmg.b.30243.
PMID16342280.
S2CID11733591.
Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". The American Journal of Psychiatry. 163 (10): 1834–7.
doi:
10.1176/ajp.2006.163.10.1834.
PMID17012699.