Clinical data | |
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Other names | Pyronaridine tetraphosphate |
Routes of administration | Oral, intramuscular injection, intravenous therapy |
ATC code |
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Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C29H32ClN5O2 |
Molar mass | 518.06 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Pyronaridine is an antimalarial drug. [1] It was first made in 1970 and has been in clinical use in China since the 1980s. [2]
In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for chloroquine. [3]
It is one of the components of the artemisinin combination therapy pyronaridine/artesunate (Pyramax). [4]
It has also been studied as a potential anticancer drug, [5] and treatment for Ebola. The combination of pyronaridine and artesunate has been evaluated to have a synergistic effect of stronger antiviral effect and less toxicity. [6] The combination of pyronaridine and artesunate is being studied as a possible treatment for moderate to severe SARS-COV-2. [7]
Clinical data | |
---|---|
Other names | Pyronaridine tetraphosphate |
Routes of administration | Oral, intramuscular injection, intravenous therapy |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C29H32ClN5O2 |
Molar mass | 518.06 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Pyronaridine is an antimalarial drug. [1] It was first made in 1970 and has been in clinical use in China since the 1980s. [2]
In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for chloroquine. [3]
It is one of the components of the artemisinin combination therapy pyronaridine/artesunate (Pyramax). [4]
It has also been studied as a potential anticancer drug, [5] and treatment for Ebola. The combination of pyronaridine and artesunate has been evaluated to have a synergistic effect of stronger antiviral effect and less toxicity. [6] The combination of pyronaridine and artesunate is being studied as a possible treatment for moderate to severe SARS-COV-2. [7]