PtK2 cells are a cell line derived from male long-nosed potoroo (Potorous tridactylis) epithelial kidney cells. [1] This cell line is used for a variety of applications in biomedical research but is particularly popular as a model for mitosis. [2]
The PtK2 cell line was established by Kirsten Walen and Spencer Brown in 1962. [3] Cells from the rat kangaroo were selected as the source of a cell line because this species has only a small number of chromosomes and these chromosomes are easily visualized under a microscope; mitosis becomes easy to observe, and the structural aspects of cell division can be closely examined. [4]
PtK2 cells are relatively large, and when grown in a monolayer, stay flat throughout the cell cycle - unlike many cells that round up during mitosis. [5] PtK2 cells are resistant to adenovirus 5, coxsackievirus B5, and poliovirus 2. They are susceptible to coxsackievirus A9, herpes simplex, vaccinia, and vesicular stomatitis (Ogden strain). [6] PtK2 cells contain intermediate filaments composed of Keratin. [7]
{{
cite book}}
: |first=
has generic name (
help)CS1 maint: multiple names: authors list (
link)
PtK2 cells are a cell line derived from male long-nosed potoroo (Potorous tridactylis) epithelial kidney cells. [1] This cell line is used for a variety of applications in biomedical research but is particularly popular as a model for mitosis. [2]
The PtK2 cell line was established by Kirsten Walen and Spencer Brown in 1962. [3] Cells from the rat kangaroo were selected as the source of a cell line because this species has only a small number of chromosomes and these chromosomes are easily visualized under a microscope; mitosis becomes easy to observe, and the structural aspects of cell division can be closely examined. [4]
PtK2 cells are relatively large, and when grown in a monolayer, stay flat throughout the cell cycle - unlike many cells that round up during mitosis. [5] PtK2 cells are resistant to adenovirus 5, coxsackievirus B5, and poliovirus 2. They are susceptible to coxsackievirus A9, herpes simplex, vaccinia, and vesicular stomatitis (Ogden strain). [6] PtK2 cells contain intermediate filaments composed of Keratin. [7]
{{
cite book}}
: |first=
has generic name (
help)CS1 maint: multiple names: authors list (
link)