Pseudomon-1 RNA | |
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![]() Consensus secondary structure of Pseudomon-1 RNAs | |
Identifiers | |
Symbol | Pseudomon-1 |
Rfam | RF01719 |
Other data | |
RNA type | sRNA |
Domain(s) | Pseudomonas |
PDB structures | PDBe |
The Pseudomon-1 RNA motif is a conserved RNA identified by bioinformatics. [1] It is used by most species whose genomes have been sequenced and that are classified within the genus Pseudomonas, and is also present in Azotobacter vinelandii, a closely related species. It is presumed to function as a non-coding RNA. Pseudomon-1 RNAs consistently have a downstream rho-independent transcription terminator.
The intergenic region containing Pseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122 [2] The genes surrounding this region suggest a similarity to Spot 42 RNA, [2] but the Pseudomonas RNA functions to regulate the AlgC enzyme [3] Based on this information, the new name ErsA for the RNA was adopted. [3] Negatively regulates major porin oprD expression responsible for uptake of carbapenem antibiotics, by base pairing with oprD 5′UTR (leading to increased bacterial resistance to meropenem). [4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility. [5]
Pseudomon-1 RNA | |
---|---|
![]() Consensus secondary structure of Pseudomon-1 RNAs | |
Identifiers | |
Symbol | Pseudomon-1 |
Rfam | RF01719 |
Other data | |
RNA type | sRNA |
Domain(s) | Pseudomonas |
PDB structures | PDBe |
The Pseudomon-1 RNA motif is a conserved RNA identified by bioinformatics. [1] It is used by most species whose genomes have been sequenced and that are classified within the genus Pseudomonas, and is also present in Azotobacter vinelandii, a closely related species. It is presumed to function as a non-coding RNA. Pseudomon-1 RNAs consistently have a downstream rho-independent transcription terminator.
The intergenic region containing Pseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122 [2] The genes surrounding this region suggest a similarity to Spot 42 RNA, [2] but the Pseudomonas RNA functions to regulate the AlgC enzyme [3] Based on this information, the new name ErsA for the RNA was adopted. [3] Negatively regulates major porin oprD expression responsible for uptake of carbapenem antibiotics, by base pairing with oprD 5′UTR (leading to increased bacterial resistance to meropenem). [4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility. [5]