PrrB/RsmZ RNA family | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of PrrB_RsmZ | |
Identifiers | |
Symbol | PrrB_RsmZ |
Rfam | RF00166 |
Other data | |
RNA type | Gene; sRNA |
Domain(s) | Bacteria |
GO | GO:0006401 GO:0006109 |
SO | SO:0000655 |
PDB structures | PDBe |
The PrrB/RsmZ RNA family are a group of related non-coding RNA molecules found in bacteria. PrrB RNA is able to phenotypically complement gacS and gacA mutants and is itself regulated by the GacS-GacA two-component signal transduction system. [1] Inactivation of the prrB gene in Pseudomonas fluorescens F113 resulted in a significant reduction of 2, 4-diacetylphloroglucinol (Phl) and hydrogen cyanide (HCN) production, while increased metabolite production was observed when prrB was overexpressed. [1] The prrB gene sequence contains a number of imperfect repeats of the consensus sequence 5′-AGGA-3′, and sequence analysis predicted a complex secondary structure featuring multiple putative stem-loops with the consensus sequences predominantly positioned at the single-stranded regions at the ends of the stem-loops. This structure is similar to the CsrB and RsmB regulatory RNAs ( CsrB/RsmB RNA family), [1] suggesting this RNA also interacts with a CsrA-like protein.
Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor. [2]
PrrB/RsmZ RNA family | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of PrrB_RsmZ | |
Identifiers | |
Symbol | PrrB_RsmZ |
Rfam | RF00166 |
Other data | |
RNA type | Gene; sRNA |
Domain(s) | Bacteria |
GO | GO:0006401 GO:0006109 |
SO | SO:0000655 |
PDB structures | PDBe |
The PrrB/RsmZ RNA family are a group of related non-coding RNA molecules found in bacteria. PrrB RNA is able to phenotypically complement gacS and gacA mutants and is itself regulated by the GacS-GacA two-component signal transduction system. [1] Inactivation of the prrB gene in Pseudomonas fluorescens F113 resulted in a significant reduction of 2, 4-diacetylphloroglucinol (Phl) and hydrogen cyanide (HCN) production, while increased metabolite production was observed when prrB was overexpressed. [1] The prrB gene sequence contains a number of imperfect repeats of the consensus sequence 5′-AGGA-3′, and sequence analysis predicted a complex secondary structure featuring multiple putative stem-loops with the consensus sequences predominantly positioned at the single-stranded regions at the ends of the stem-loops. This structure is similar to the CsrB and RsmB regulatory RNAs ( CsrB/RsmB RNA family), [1] suggesting this RNA also interacts with a CsrA-like protein.
Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor. [2]