| PGGT1B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | PGGT1B, BGGI, GGTI, protein geranylgeranyltransferase type I subunit beta | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602031; MGI: 1917514; HomoloGene: 3685; GeneCards: PGGT1B; OMA: PGGT1B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT1B gene. [5]
Function
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164219 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024477 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Protein geranylgeranyltransferase type I subunit beta". Retrieved 2018-09-21.
Further reading
- Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M (2003). "Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor". Clin. Exp. Metastasis. 20 (6): 561–7. doi: 10.1023/a:1025898316728. PMID 14598891. S2CID 24756418.
- Reid TS, Terry KL, Casey PJ, Beese LS (October 2004). "Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity". J. Mol. Biol. 343 (2): 417–33. doi: 10.1016/j.jmb.2004.08.056. PMID 15451670.
- Comabella M, Craig DW, Morcillo-Suárez C, Río J, Navarro A, Fernández M, Martin R, Montalban X (August 2009). "Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis". Arch. Neurol. 66 (8): 972–8. doi: 10.1001/archneurol.2009.150. PMID 19667218.
- Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB (May 2010). "Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer". Cancer Prev Res (Phila). 3 (5): 597–603. doi: 10.1158/1940-6207.CAPR-10-0007. PMID 20403997.
- Virtanen SS, Sandholm J, Yegutkin G, Kalervo Väänänen H, Härkönen PL (August 2010). "Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells". Cell Biol. Int. 34 (8): 815–26. doi: 10.1042/CBI20090288. PMID 20446922. S2CID 44993117.
- Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ (February 2012). "Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 302 (4): L420–8. doi: 10.1152/ajplung.00312.2011. PMID 22160308. S2CID 13448673.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |
| PGGT1B | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | PGGT1B, BGGI, GGTI, protein geranylgeranyltransferase type I subunit beta | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602031; MGI: 1917514; HomoloGene: 3685; GeneCards: PGGT1B; OMA: PGGT1B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT1B gene. [5]
Function
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164219 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024477 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Protein geranylgeranyltransferase type I subunit beta". Retrieved 2018-09-21.
Further reading
- Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M (2003). "Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor". Clin. Exp. Metastasis. 20 (6): 561–7. doi: 10.1023/a:1025898316728. PMID 14598891. S2CID 24756418.
- Reid TS, Terry KL, Casey PJ, Beese LS (October 2004). "Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity". J. Mol. Biol. 343 (2): 417–33. doi: 10.1016/j.jmb.2004.08.056. PMID 15451670.
- Comabella M, Craig DW, Morcillo-Suárez C, Río J, Navarro A, Fernández M, Martin R, Montalban X (August 2009). "Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis". Arch. Neurol. 66 (8): 972–8. doi: 10.1001/archneurol.2009.150. PMID 19667218.
- Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB (May 2010). "Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer". Cancer Prev Res (Phila). 3 (5): 597–603. doi: 10.1158/1940-6207.CAPR-10-0007. PMID 20403997.
- Virtanen SS, Sandholm J, Yegutkin G, Kalervo Väänänen H, Härkönen PL (August 2010). "Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells". Cell Biol. Int. 34 (8): 815–26. doi: 10.1042/CBI20090288. PMID 20446922. S2CID 44993117.
- Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ (February 2012). "Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 302 (4): L420–8. doi: 10.1152/ajplung.00312.2011. PMID 22160308. S2CID 13448673.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |