 | This article relies largely or entirely on a
single source. (February 2022) |
Procoagulant platelets are a functional subgroup of platelets with distinct properties in physiological haemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro-haemostatic function by retaining α-granule proteins on their membranes. [1] While a low level of procoagulant platelets is associated with impaired platelet function and bleeding diathesis high levels have been shown to worsen thrombotic events. [1] [2]
References
- ^
a
b Aliotta, A; Alberio, L (Feb 24, 2021).
"Thrombocytopathies: Not Just Aggregation Defects - The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 894.
doi:
10.3390/jcm10050894.
PMC
7956450.
PMID
33668091.
This article incorporates text available under the
CC BY 4.0 license.
- ^ Agbani, E; Poole, A (Nov 16, 2017). "Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis". Blood. 130 (20): 2171–2179. doi: 10.1182/blood-2017-05-787259. hdl: 1983/75ed79a3-9349-48f6-a1b3-803d416ce612. PMID 28972013. S2CID 206954340.
 | This cardiovascular system article is a stub. You can help Wikipedia by expanding it. |
| This article relies largely or entirely on a
single source. (February 2022) |
Procoagulant platelets are a functional subgroup of platelets with distinct properties in physiological haemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro-haemostatic function by retaining α-granule proteins on their membranes. [1] While a low level of procoagulant platelets is associated with impaired platelet function and bleeding diathesis high levels have been shown to worsen thrombotic events. [1] [2]
References
- ^
a
b Aliotta, A; Alberio, L (Feb 24, 2021).
"Thrombocytopathies: Not Just Aggregation Defects - The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 894.
doi:
10.3390/jcm10050894.
PMC
7956450.
PMID
33668091.
This article incorporates text available under the
CC BY 4.0 license.
- ^ Agbani, E; Poole, A (Nov 16, 2017). "Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis". Blood. 130 (20): 2171–2179. doi: 10.1182/blood-2017-05-787259. hdl: 1983/75ed79a3-9349-48f6-a1b3-803d416ce612. PMID 28972013. S2CID 206954340.
|
| This cardiovascular system article is a stub. You can help Wikipedia by expanding it. |