PrfA thermoregulator UTR | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of PrfA | |
Identifiers | |
Symbol | PrfA |
Rfam | RF00038 |
Other data | |
RNA type | Cis-reg; thermoregulator |
Domain(s) | Bacteria |
SO | SO:0000233 |
PDB structures | PDBe |
The PrfA thermoregulator UTR is an RNA thermometer found in the 5' UTR of the prfA gene. [1] In Listeria monocytogenes, virulence genes are maximally expressed at 37 °C ( human body temperature) but are almost silent at 30 °C. [2] The genes are controlled by PrfA, a transcriptional activator whose expression is thermoregulated. [3] It has been shown that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region. [1] It is thought that at 37 °C, the hairpin structure 'melts' and the SD sequence is unmasked. [1]
PrfA thermoregulator UTR | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of PrfA | |
Identifiers | |
Symbol | PrfA |
Rfam | RF00038 |
Other data | |
RNA type | Cis-reg; thermoregulator |
Domain(s) | Bacteria |
SO | SO:0000233 |
PDB structures | PDBe |
The PrfA thermoregulator UTR is an RNA thermometer found in the 5' UTR of the prfA gene. [1] In Listeria monocytogenes, virulence genes are maximally expressed at 37 °C ( human body temperature) but are almost silent at 30 °C. [2] The genes are controlled by PrfA, a transcriptional activator whose expression is thermoregulated. [3] It has been shown that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region. [1] It is thought that at 37 °C, the hairpin structure 'melts' and the SD sequence is unmasked. [1]