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IUPAC name
(1E,2E,4E)-1-[5-[(4-hydroxyphenyl)methyl]-2,4-dioxopyrrolidin-3-ylidene]-4,6-dimethylocta-2,4-dien-1-olate
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3D model (
JSmol)
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ChemSpider | |
PubChem
CID
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Related compounds
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Pretenellin B |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Pretenellin A is a secondary metabolite in Aspergillus oryzae. [1] Pretenellin A is a substrate for tenellin because it undergoes an oxidative ring expansion to form Pretenellin B followed by N-hydroxylation to form Tenellin, an iron chelator in entomopathegnic fungus. [2]
Pretenellin A is biosynthesized using acetate in the initiation module. The acetate molecule is then extended four times by iterative PKS (Figure 1). The specific methylations occur after the first and second elongation module. After the four elongation module, the β-ketopentaketide is brought into close proximity with tyrosine which is attached to a non-ribosomal peptide synthetase (NRPS) (Figure 2). When the iterative PKS interacts with the NRPS system Pretenellin A is released, acting as a well-regulated off-loading mechanism thus releasing Pretenellin A. [1] [3]
![]() | This article has multiple issues. Please help
improve it or discuss these issues on the
talk page. (
Learn how and when to remove these template messages)
|
![]() | |
Names | |
---|---|
IUPAC name
(1E,2E,4E)-1-[5-[(4-hydroxyphenyl)methyl]-2,4-dioxopyrrolidin-3-ylidene]-4,6-dimethylocta-2,4-dien-1-olate
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
PubChem
CID
|
|
| |
| |
Related compounds | |
Related compounds
|
Pretenellin B |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Pretenellin A is a secondary metabolite in Aspergillus oryzae. [1] Pretenellin A is a substrate for tenellin because it undergoes an oxidative ring expansion to form Pretenellin B followed by N-hydroxylation to form Tenellin, an iron chelator in entomopathegnic fungus. [2]
Pretenellin A is biosynthesized using acetate in the initiation module. The acetate molecule is then extended four times by iterative PKS (Figure 1). The specific methylations occur after the first and second elongation module. After the four elongation module, the β-ketopentaketide is brought into close proximity with tyrosine which is attached to a non-ribosomal peptide synthetase (NRPS) (Figure 2). When the iterative PKS interacts with the NRPS system Pretenellin A is released, acting as a well-regulated off-loading mechanism thus releasing Pretenellin A. [1] [3]