Interstate 295 (abbreviated I-295) in New Jersey and Delaware is a bypass route from a junction with Interstate 95 south of Wilmington, Delaware to another junction with I-95 north of Trenton, New Jersey. The route runs parallel with the New Jersey Turnpike for most of its course. Interstate 295 is an auxiliary Interstate Highway, designated as a bypass around Philadelphia, Pennsylvania. Interstate 95 serves the city directly, connecting it with Wilmington and Trenton, whereas I-295 bypasses the city running east of the Delaware River.

Interstate 95 was originally supposed to continue northeast from the routes' junction near Trenton on the proposed Somerset Freeway, but this plan was cancelled, limiting I-295's capability as a true bypass between Baltimore and New York City. Today, traffic on Interstate 295 is directed to take Interstate 195 (or surface street connections further south) to the New Jersey Turnpike to reach New York City. The same route is prescribed for traffic on I-95 in Pennsylvania and near Trenton to bridge the gap with I-95 further north.