Point of Departure or Points of Departure may refer to:

• Point of Departure (film), a 1966 Australian TV film
• "Points of Departure" (Babylon 5), a 1994 episode

• Point of Departure, an autobiography by James Cameron (1911–1985)
• The Point of Departure, an autobiography by Robin Cook, 2003
• Point of Departure (play), or Eurydice, by Jean Anouilh, 1941
• Points of Departure, a political memoir by Dalton Camp, 1979
• Point of departure (or divergence), a concept in alternative history literature

• Point of Departure (Gary McFarland album), 1963
• Point of Departure (Andrew Hill album), 1965

• Departure (disambiguation)
• Takeoff, phase of flight from moving along the ground to flying in the air

This disambiguation page lists articles associated with the title Point of Departure.
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