Released pneumolysin will aid the bacteria during colonization by facilitating adherence to the host,[5] during invasion by damaging host cells[6] and during infection by interfering with the host immune response.[7]
^Rossjohn, J; Gilbert, RJ; Crane, D; Morgan, PJ; et al. (Nov 27, 1998). "The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae". Journal of Molecular Biology. 284 (2): 449–61.
doi:
10.1006/jmbi.1998.2167.
PMID9813129.
^Marriott, HM; Mitchell, TJ; Dockrell, DH (September 2008). "Pneumolysin: A double-edged sword during the host-pathogen interaction". Current Molecular Medicine. 8 (6): 497–509.
doi:
10.2174/156652408785747924.
PMID18781957.
^Baba, H; Kawamura, I; Kohda, C; Nomura, T; et al. (February 16, 2001). "Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins". Biochemical and Biophysical Research Communications. 281 (1): 37–44.
doi:
10.1006/bbrc.2001.4297.
PMID11178957.
^Cockeran, R; Anderson, R; Feldman, C (June 2002). "The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection". Current Opinion in Infectious Diseases. 15 (3): 235–9.
doi:
10.1097/00001432-200206000-00004.
PMID12015456.
^Wheeler, J; Freeman, R; Steward, M; Henderson, K; et al. (September 1999). "Detection of pneumolysin in sputum". Journal of Medical Microbiology. 48 (9): 863–6.
doi:
10.1099/00222615-48-9-863.
PMID10482298.
^Rajalakshmi, B; Kanungo, R; Srinivasan, S; Badrinath, S (Oct–Dec 2002). "Pneumolysin in urine: A rapid antigen detection method to diagnose pneumococcal pneumonia in children". Indian Journal of Medical Microbiology. 20 (4): 183–6.
PMID17657067.
Released pneumolysin will aid the bacteria during colonization by facilitating adherence to the host,[5] during invasion by damaging host cells[6] and during infection by interfering with the host immune response.[7]
^Rossjohn, J; Gilbert, RJ; Crane, D; Morgan, PJ; et al. (Nov 27, 1998). "The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae". Journal of Molecular Biology. 284 (2): 449–61.
doi:
10.1006/jmbi.1998.2167.
PMID9813129.
^Marriott, HM; Mitchell, TJ; Dockrell, DH (September 2008). "Pneumolysin: A double-edged sword during the host-pathogen interaction". Current Molecular Medicine. 8 (6): 497–509.
doi:
10.2174/156652408785747924.
PMID18781957.
^Baba, H; Kawamura, I; Kohda, C; Nomura, T; et al. (February 16, 2001). "Essential role of domain 4 of pneumolysin from Streptococcus pneumoniae in cytolytic activity as determined by truncated proteins". Biochemical and Biophysical Research Communications. 281 (1): 37–44.
doi:
10.1006/bbrc.2001.4297.
PMID11178957.
^Cockeran, R; Anderson, R; Feldman, C (June 2002). "The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection". Current Opinion in Infectious Diseases. 15 (3): 235–9.
doi:
10.1097/00001432-200206000-00004.
PMID12015456.
^Wheeler, J; Freeman, R; Steward, M; Henderson, K; et al. (September 1999). "Detection of pneumolysin in sputum". Journal of Medical Microbiology. 48 (9): 863–6.
doi:
10.1099/00222615-48-9-863.
PMID10482298.
^Rajalakshmi, B; Kanungo, R; Srinivasan, S; Badrinath, S (Oct–Dec 2002). "Pneumolysin in urine: A rapid antigen detection method to diagnose pneumococcal pneumonia in children". Indian Journal of Medical Microbiology. 20 (4): 183–6.
PMID17657067.