PLAKOPHILIN-3

PKP3
Identifiers
Aliases	PKP3, plakophilin 3
External IDs	OMIM: 605561; MGI: 1891830; HomoloGene: 5200; GeneCards: PKP3; OMA: PKP3 - orthologs
Gene location ( Human)
Chr.	Chromosome 11 (human)
End	404,908 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	140,670,423 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; mucosa of pharynx; ; human penis; ; skin of arm; ; mucosa of transverse colon; ; mucosa of ileum; ; nipple; ; vulva; ; gums;
	Top expressed in
	lip; ; epidermis; ; hair follicle; ; esophagus; ; skin of external ear; ; corneal stroma; ; skin of abdomen; ; skin of back; ; saccule; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	alpha-catenin binding; cell adhesion molecule binding; cadherin binding involved in cell-cell adhesion; RNA binding; protein binding; enzyme binding; translation regulator activity; cadherin binding;
Cellular component	desmosome; nucleus; cell-cell junction; cornified envelope; nucleoplasm; plasma membrane; cell junction; messenger ribonucleoprotein complex; cytoplasm;
Biological process	desmosome assembly; cell adhesion; keratinization; cornification; regulation of translation; positive regulation of gene expression; negative regulation of mRNA catabolic process; protein localization to plasma membrane; cell-cell adhesion; cell-cell junction assembly;
	Sources: Amigo / QuickGO
Orthologs
	11187
	56460
	ENSG00000184363
	ENSMUSG00000054065
	Q9Y446
	Q9QY23
	NM_007183; NM_001303029
	NM_001162924; NM_019762
	NP_001289958; NP_009114
	NP_001156396; NP_062736
	Wikidata
View/Edit Human	View/Edit Mouse

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.^[5]^[6]

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.^[6]

Interactions

PKP3 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184363 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054065 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi: 10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
^ ^a ^b "Entrez Gene: PKP3 plakophilin 3".
^ ^a ^b ^c ^d Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi: 10.1083/jcb.200303036. hdl: 1854/LU-210987. PMC 2172904. PMID 12707304.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi: 10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi: 10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bonné S, van Hengel J, Nollet F, Kools P, van Roy F (1999). "Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells". J. Cell Sci. 112 (14): 2265–76. doi: 10.1242/jcs.112.14.2265. hdl: 1854/LU-113819. PMID 10381383.
Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis". J. Cell Sci. 113 (13): 2471–83. doi: 10.1242/jcs.113.13.2471. PMID 10852826.
Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi: 10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
Papagerakis S, Shabana AH, Depondt J, Gehanno P, Forest N (2003). "Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters". Hum. Pathol. 34 (6): 565–72. doi: 10.1016/S0046-8177(03)00174-6. PMID 12827610.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode: 2004PNAS..10112130B. doi: 10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200. PMID 15778465.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200. PMID 15951569.
Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke WW (2006). "Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules". Mol. Biol. Cell. 17 (3): 1388–98. doi: 10.1091/mbc.E05-08-0708. PMC 1382326. PMID 16407409.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi: 10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonné S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007). "The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression". FEBS Lett. 581 (8): 1617–24. doi: 10.1016/j.febslet.2007.03.026. PMC 2938730. PMID 17391671.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184363 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054065 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10374265-5] Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi: 10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.

[entrez-6] "Entrez Gene: PKP3 plakophilin 3".

[pmid12707304-7] Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi: 10.1083/jcb.200303036. hdl: 1854/LU-210987. PMC 2172904. PMID 12707304.

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Function

Interactions

References

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References

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