![]() | |
Names | |
---|---|
IUPAC name
(1R)-1,4-Anhydro-1-(N2-formylglycinamido)-D-ribitol 5-(dihydrogen phosphate)
| |
Systematic IUPAC name
[(2R,3S,4R,5R)-5-(2-Formamidoacetamido)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
Other names
Formylglycinamide ribonucleotide,
Formylglycinamide ribotide, FGAR | |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
MeSH | Phosphoribosyl-N-formylglycineamide |
PubChem
CID
|
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C8H15N2O9P | |
Molar mass | 314.187 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Phosphoribosyl-N-formylglycineamide (or FormylGlycinAmideRibotide, FGAR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. [1] [2] The vitamins thiamine [3] and cobalamin [4] also contain fragments derived from FGAR. [5]
FGAR is formed when the enzyme phosphoribosylglycinamide formyltransferase adds a formyl group from 10-formyltetrahydrofolate to glycineamide ribonucleotide (GAR) in reaction EC 2.1.2.2: [6]
The biosynthesis pathway next converts FGAR to an amidine by the action of phosphoribosylformylglycinamidine synthase ( EC 6.3.5.3), transferring an amino group from glutamine and giving 5'-phosphoribosylformylglycinamidine (FGAM) in a reaction that also requires ATP: [6]
![]() | |
Names | |
---|---|
IUPAC name
(1R)-1,4-Anhydro-1-(N2-formylglycinamido)-D-ribitol 5-(dihydrogen phosphate)
| |
Systematic IUPAC name
[(2R,3S,4R,5R)-5-(2-Formamidoacetamido)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
Other names
Formylglycinamide ribonucleotide,
Formylglycinamide ribotide, FGAR | |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
MeSH | Phosphoribosyl-N-formylglycineamide |
PubChem
CID
|
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C8H15N2O9P | |
Molar mass | 314.187 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Phosphoribosyl-N-formylglycineamide (or FormylGlycinAmideRibotide, FGAR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. [1] [2] The vitamins thiamine [3] and cobalamin [4] also contain fragments derived from FGAR. [5]
FGAR is formed when the enzyme phosphoribosylglycinamide formyltransferase adds a formyl group from 10-formyltetrahydrofolate to glycineamide ribonucleotide (GAR) in reaction EC 2.1.2.2: [6]
The biosynthesis pathway next converts FGAR to an amidine by the action of phosphoribosylformylglycinamidine synthase ( EC 6.3.5.3), transferring an amino group from glutamine and giving 5'-phosphoribosylformylglycinamidine (FGAM) in a reaction that also requires ATP: [6]