Phorbol-12-myristate-13-acetate-induced protein 1 is a
protein that in humans is encoded by the PMAIP1gene, and is also known as Noxa.[3][4][5]
Noxa (Latin for damage) is a pro-
apoptotic member of the
Bcl-2 protein family.[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor
p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
^Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8.
doi:
10.1038/sj.onc.1206655.
PMID12879012.
^Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.
^
abOda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.
Phorbol-12-myristate-13-acetate-induced protein 1 is a
protein that in humans is encoded by the PMAIP1gene, and is also known as Noxa.[3][4][5]
Noxa (Latin for damage) is a pro-
apoptotic member of the
Bcl-2 protein family.[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor
p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
^Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8.
doi:
10.1038/sj.onc.1206655.
PMID12879012.
^Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.
^
abOda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8.
Bibcode:
2000Sci...288.1053O.
doi:
10.1126/science.288.5468.1053.
PMID10807576.