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Perené
Location
Country	Peru
Physical characteristics
Source
• location	confluence of the Chanchamayo and Paucartambo Rivers, Peru
• coordinates	10°57′06″S 75°17′00″W / 10.95167°S 75.28333°W / -10.95167; -75.28333
• elevation	650 m (2,130 ft)
Mouth	Tambo River
• location	confluence with Ene River, Peru
• coordinates	11°09′54″S 74°14′03″W / 11.16500°S 74.23417°W / -11.16500; -74.23417
• elevation	400 m (1,300 ft)
Length	165 km (103 mi)

The Perené River ( Spanish: Río Perené) is a Peruvian river on the eastern slopes of the South American Andes.

It is formed at the confluence of the Chanchamayo and Paucartambo Rivers, 15 km (9.3 mi) above the community of Perené, actually two pueblos of Santa Ana and Pampa Silva divided by the river, at 650 m (2,130 ft) above sea level.

The 165 km (103 mi) river flows in a south-easterly direction. The Perené joins the Ene River, 10 km (6.2 mi) below the community of Puerto Ocopa, at 400 m (1,300 ft) above sea level, and is called the Tambo River from then on.