FstAT | |
---|---|
Identifiers | |
Symbol | fstAT |
Rfam | RF01797 |
Other data | |
RNA type | Gene; antitoxin |
Domain(s) | Enterococcus faecalis |
PDB structures | PDBe |
Fst Type I toxin-antitoxin system | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Fst_toxin | ||||||||
Pfam | PF13955 | ||||||||
TCDB | 1.C.64 | ||||||||
OPM superfamily | 225 | ||||||||
OPM protein | 2kv5 | ||||||||
|
The par stability determinant is a 400 bp locus of the pAD1 plasmid which encodes a type I toxin-antitoxin system in Enterococcus faecalis. [1] [2] It was the first such plasmid addiction module to be found in gram-positive bacteria. [3]
The par locus contains two genes: fst which encodes a 33- amino acid toxic protein and a gene for RNAII, the small RNA anti-toxin which inhibits fst translation. [4] The two genes are found on opposite DNA strands and share a 5' region which is where they are thought to have an antisense interaction. [4] Their RNA secondary structures have been predicted computationally, the complementary regions appear to be presented on exposed loops for interaction. [4]
par maintains pAD1 by means of post-segregational killing (PSK). If a daughter cell does not inherit the par locus, the unstable RNAII will quickly degrade leaving the long-lived fst toxin to damage or kill the daughter cell. [5]
FstAT | |
---|---|
Identifiers | |
Symbol | fstAT |
Rfam | RF01797 |
Other data | |
RNA type | Gene; antitoxin |
Domain(s) | Enterococcus faecalis |
PDB structures | PDBe |
Fst Type I toxin-antitoxin system | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Fst_toxin | ||||||||
Pfam | PF13955 | ||||||||
TCDB | 1.C.64 | ||||||||
OPM superfamily | 225 | ||||||||
OPM protein | 2kv5 | ||||||||
|
The par stability determinant is a 400 bp locus of the pAD1 plasmid which encodes a type I toxin-antitoxin system in Enterococcus faecalis. [1] [2] It was the first such plasmid addiction module to be found in gram-positive bacteria. [3]
The par locus contains two genes: fst which encodes a 33- amino acid toxic protein and a gene for RNAII, the small RNA anti-toxin which inhibits fst translation. [4] The two genes are found on opposite DNA strands and share a 5' region which is where they are thought to have an antisense interaction. [4] Their RNA secondary structures have been predicted computationally, the complementary regions appear to be presented on exposed loops for interaction. [4]
par maintains pAD1 by means of post-segregational killing (PSK). If a daughter cell does not inherit the par locus, the unstable RNAII will quickly degrade leaving the long-lived fst toxin to damage or kill the daughter cell. [5]