PUNLMP (Papillary Urothelial Neoplasm of Low Malignant Potential) | |
---|---|
Micrograph of a PUNLMP. Intermediate magnification. H&E stain. | |
Specialty | Urology, pathology |
Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an exophytic (outward growing), (microscopically) nipple-shaped (or papillary) pre-malignant growth of the lining of the upper genitourinary tract (the urothelium), which includes the renal pelvis, ureters, urinary bladder and part of the urethra.
PUNLMP is pronounced pun-lump, like the words pun and lump.
As their name suggests, PUNLMPs are neoplasms, i.e. clonal cellular proliferations, that are thought to have a low probability of developing into urothelial cancer, i.e. a malignancy such as bladder cancer.
PUNLMPs can lead to blood in the urine ( hematuria) or may be asymptomatic.[ citation needed]
PUNLMPs are exophytic lesions that appear friable to the naked eye and when imaged during cystoscopy. They are definitively diagnosed after removal by microscopic examination by pathologists.[ citation needed]
Histologically, they have a papillary architecture with slender fibro vascular cores and rare basal mitoses. The papillae rarely fuse and uncommonly branch. Cytologically, they have uniform nuclear enlargement.[ citation needed]
They cannot be reliably differentiated from low grade papillary urothelial carcinomas using cytology, [1] and their diagnosis (vis-a-vis low grade papillary urothelial carcinoma) has a poor inter-rater reliability. [2]
Pathologic grading and staging tumors are: graded by the degree of cellular atypia (G1->G3), and staged:[ citation needed]
PUNLMPs are treated like non-invasive low grade papillary urothelial carcinomas, [1] excision and regular follow-up cystoscopies.
There is a rare occurrence of a pelvic recurrence of a low-grade superficial TCC after cystectomy. Delayed presentation with recurrent low-grade urothelial carcinoma is an unusual entity and potential mechanism of traumatic implantation should be considered. Characteristically low-grade tumors are resistant to systemic chemotherapy and curative-intent surgical resection of the tumor should be considered.[ citation needed]
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
PUNLMP (Papillary Urothelial Neoplasm of Low Malignant Potential) | |
---|---|
Micrograph of a PUNLMP. Intermediate magnification. H&E stain. | |
Specialty | Urology, pathology |
Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an exophytic (outward growing), (microscopically) nipple-shaped (or papillary) pre-malignant growth of the lining of the upper genitourinary tract (the urothelium), which includes the renal pelvis, ureters, urinary bladder and part of the urethra.
PUNLMP is pronounced pun-lump, like the words pun and lump.
As their name suggests, PUNLMPs are neoplasms, i.e. clonal cellular proliferations, that are thought to have a low probability of developing into urothelial cancer, i.e. a malignancy such as bladder cancer.
PUNLMPs can lead to blood in the urine ( hematuria) or may be asymptomatic.[ citation needed]
PUNLMPs are exophytic lesions that appear friable to the naked eye and when imaged during cystoscopy. They are definitively diagnosed after removal by microscopic examination by pathologists.[ citation needed]
Histologically, they have a papillary architecture with slender fibro vascular cores and rare basal mitoses. The papillae rarely fuse and uncommonly branch. Cytologically, they have uniform nuclear enlargement.[ citation needed]
They cannot be reliably differentiated from low grade papillary urothelial carcinomas using cytology, [1] and their diagnosis (vis-a-vis low grade papillary urothelial carcinoma) has a poor inter-rater reliability. [2]
Pathologic grading and staging tumors are: graded by the degree of cellular atypia (G1->G3), and staged:[ citation needed]
PUNLMPs are treated like non-invasive low grade papillary urothelial carcinomas, [1] excision and regular follow-up cystoscopies.
There is a rare occurrence of a pelvic recurrence of a low-grade superficial TCC after cystectomy. Delayed presentation with recurrent low-grade urothelial carcinoma is an unusual entity and potential mechanism of traumatic implantation should be considered. Characteristically low-grade tumors are resistant to systemic chemotherapy and curative-intent surgical resection of the tumor should be considered.[ citation needed]
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)