Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an
enzyme regulator that in humans is encoded by the PPP2R2Agene.[5]
Function
The product of this gene belongs to the phosphatase 2 regulatory subunit B family.
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (Apr 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97.
doi:
10.1021/bi00229a001.
PMID1849734.
Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51.
doi:
10.2174/1570162052772988.
PMID15638722.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an
enzyme regulator that in humans is encoded by the PPP2R2Agene.[5]
Function
The product of this gene belongs to the phosphatase 2 regulatory subunit B family.
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (Apr 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97.
doi:
10.1021/bi00229a001.
PMID1849734.
Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51.
doi:
10.2174/1570162052772988.
PMID15638722.