Apoptosis-stimulating of p53 protein 1 is a
protein that in humans is encoded by the PPP1R13Bgene.[5][6]
This gene encodes a member of the
ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[6]
Liu ZJ, Lu X, Zhang Y, et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53". FEBS Lett. 579 (7): 1587–90.
doi:
10.1016/j.febslet.2005.01.069.
PMID15757645.
S2CID34118663.
Apoptosis-stimulating of p53 protein 1 is a
protein that in humans is encoded by the PPP1R13Bgene.[5][6]
This gene encodes a member of the
ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[6]
Liu ZJ, Lu X, Zhang Y, et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53". FEBS Lett. 579 (7): 1587–90.
doi:
10.1016/j.febslet.2005.01.069.
PMID15757645.
S2CID34118663.