PPP1R10

PPP1R10
Identifiers
Aliases	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDs	OMIM: 603771; MGI: 1289273; HomoloGene: 2033; GeneCards: PPP1R10; OMA: PPP1R10 - orthologs
Gene location ( Human)
Chr.	Chromosome 6 (human)
End	30,618,612 bp
Gene location ( Mouse)
Chr.	Chromosome 17 (mouse)
End	36,243,175 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; sural nerve; ; gallbladder; ; tonsil; ; granulocyte; ; appendix; ; urinary bladder; ; right uterine tube; ; rectum; ; Achilles tendon;
	Top expressed in
	primary oocyte; ; zygote; ; tail of embryo; ; testicle; ; secondary oocyte; ; genital tubercle; ; spermatid; ; spermatocyte; ; ventricular zone; ; uterus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity; DNA binding; metal ion binding; RNA binding; protein binding;
Cellular component	chromatin; PTW/PP1 phosphatase complex; nucleus; nucleoplasm; nuclear body;
Biological process	negative regulation of catalytic activity; protein import into nucleus; negative regulation of cardiac muscle cell apoptotic process; positive regulation of telomere maintenance; negative regulation of phosphoprotein phosphatase activity; negative regulation of mitotic DNA damage checkpoint;
	Sources: Amigo / QuickGO
Orthologs
	5514
	52040
ENSG00000227804; ENSG00000238104; ENSG00000206489; ENSG00000230995; ENSG00000235291;
	ENSG00000231737; ENSG00000204569
	ENSMUSG00000039220
	Q96QC0
	Q80W00
	NM_002714; NM_001376195
	NM_001163818; NM_175934; NM_001357740
	NP_002705; NP_001363124
	NP_001157290; NP_001344669; NP_001390493
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.^[5]^[6]^[7]

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 ( PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.^[7]

References

^ ^a ^b ^c ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi: 10.1074/jbc.273.7.4089. PMID 9461602.
^ Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi: 10.1006/bbrc.1998.9354. PMID 9784381.
^ ^a ^b "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Totaro A, Rommens JM, Grifa A, et al. (1997). "Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region". Genomics. 31 (3): 319–26. doi: 10.1006/geno.1996.0054. PMID 8838313.
Kreivi JP, Trinkle-Mulcahy L, Lyon CE, et al. (1998). "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity". FEBS Lett. 420 (1): 57–62. doi: 10.1016/S0014-5793(97)01485-3. PMID 9450550. S2CID 23856958.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim YM, Watanabe T, Allen PB, et al. (2003). "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation". J. Biol. Chem. 278 (16): 13819–28. doi: 10.1074/jbc.M209621200. PMID 12574161.
Reeder JE, Sowden MP, Messing EM, et al. (2003). "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line". Cancer Cell International. 3 (1): 12. doi: 10.1186/1475-2867-3-12. PMC 183861. PMID 12914669.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055. PMID 14574404.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi: 10.1101/gr.2334104. PMC 442148. PMID 15231748.
Raha-Chowdhury R, Andrews SR, Gruen JR (2005). "CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease". Brain Res. Mol. Brain Res. 138 (1): 70–83. doi: 10.1016/j.molbrainres.2005.04.001. PMID 15894402.
Landsverk HB, Kirkhus M, Bollen M, et al. (2006). "PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner". Biochem. J. 390 (Pt 3): 709–17. doi: 10.1042/BJ20050678. PMC 1199665. PMID 15907195.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi: 10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lee SJ, Lim CJ, Min JK, et al. (2007). "Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2". Cell Death Differ. 14 (6): 1106–16. doi: 10.1038/sj.cdd.4402111. PMID 17318220.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9461602-5] Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi: 10.1074/jbc.273.7.4089. PMID 9461602.

[pmid9784381-6] Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi: 10.1006/bbrc.1998.9354. PMID 9784381.

[entrez-7] "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

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